4930557A04Rik Activators
Chemical activators of H2A histone family member L3, such as Trichostatin A, SAHA, Nicotinamide, Valproic acid, Sodium butyrate, MS-275, Scriptaid, RGFP966, PCI-34051, Panobinostat, Belinostat, and Mocetinostat, function primarily through their inhibition of histone deacetylases (HDACs). The inhibition of HDACs by these chemicals leads to an increase in the acetylation levels of histones, including H2A histone family member L3. The acetylation of H2A histone family member L3 is a key regulatory modification that relaxes the chromatin structure, allowing for a more transcriptionally active state. This modification is essential for the transcriptional machinery to access DNA, thereby facilitating the transcription of genes.
Chemicals such as Trichostatin A and SAHA are known to broadly target HDACs, thereby increasing the acetylation of H2A histone family member L3 among other histone proteins. On the other hand, compounds like PCI-34051 have a more targeted approach, specifically inhibiting HDAC8, which still results in the enhanced acetylation of H2A histone family member L3. Regardless of their specificity, the result is a change in the chromatin landscape, resulting in the activation of H2A histone family member L3. This activation promotes a chromatin conformation that is more open and permissive for gene expression. The consistent theme across the action of these chemical activators is the pivotal role of histone acetylation in modulating chromatin structure, thereby governing the accessibility of transcriptional activators and other factors necessary for gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase (HDAC), leading to an increase in acetylation of histones, including H2A histone family member L3. This acetylation directly activates the protein by allowing a more relaxed chromatin state for transcriptional activation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA, also known as Vorinostat, functions similarly to Trichostatin A by inhibiting HDACs, thus increasing acetylation levels on histones such as H2A histone family member L3, leading to its activation and a more transcriptionally active chromatin configuration. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is an HDAC inhibitor that can lead to increased acetylation of H2A histone family member L3, thereby activating the protein and influencing gene expression by altering chromatin structure. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
As an HDAC inhibitor, Valproic acid increases acetylation of histones like H2A histone family member L3, thus activating the protein and promoting a chromatin state that facilitates gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as an HDAC inhibitor, leading to the acetylation and subsequent activation of H2A histone family member L3, contributing to the loosening of chromatin structure and gene activation. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275, an HDAC inhibitor, increases the acetylation levels of histone proteins including H2A histone family member L3, thus activating the protein by modulating chromatin architecture to favor transcriptional activity. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
Scriptaid functions as an HDAC inhibitor, which leads to increased acetylation and activation of H2A histone family member L3, thereby altering chromatin structure to a state more conducive to gene expression. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966 is an HDAC inhibitor that promotes acetylation of H2A histone family member L3, resulting in the protein's activation and influencing chromatin dynamics to enhance gene transcription. | ||||||
PCI-34051 | 950762-95-5 | sc-364566 sc-364566A | 10 mg 100 mg | $185.00 $1638.00 | 5 | |
PCI-34051 acts as an HDAC8-specific inhibitor, leading to increased acetylation and subsequent activation of H2A histone family member L3, thus affecting chromatin structure and transcriptional regulation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent HDAC inhibitor that increases the acetylation of histones such as H2A histone family member L3, activating the protein and promoting an open chromatin conformation conducive to transcriptional activation. | ||||||