4930443G12Rik Inhibitors
The chemical class referred to as Slc25a54 Inhibitors would include a variety of compounds that can indirectly impact the function of Slc25a54 through modulation of mitochondrial function and cellular energy metabolism. This indirect approach targets the essential upstream processes that are prerequisites for the proper function of Slc25a54. For instance, bongkrekic acid and carboxyatractyloside interfere with the adenine nucleotide translocase, affecting the transport of ADP and ATP across the mitochondrial membrane which is crucial for maintaining the energy balance that Slc25a54 relies on.
Additionally, compounds such as iodoacetate, oligomycin, rotenone, antimycin A, and atractyloside disrupt various components of the electron transport chain and ATP synthesis. This disruption leads to a decrease in the ATP levels available for ATP-dependent transporters like Slc25a54, potentially inhibiting its function. 2-Deoxy-D-glucose, azide, cyanide, FCCP, and valinomycin further contribute to the alteration of mitochondrial function and cellular energetics, thereby influencing the activity of Slc25a54.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $418.00 | 10 | |
An inhibitor of the adenine nucleotide translocase (ANT) that can indirectly affect ATP/ADP transport across the mitochondrial membrane, potentially altering Slc25a54 activity. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $56.00 $97.00 | ||
An inhibitor of glycolytic enzymes that can reduce the availability of cellular ATP, potentially affecting ATP-dependent transporters like Slc25a54. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
An inhibitor of ATP synthase that can decrease mitochondrial ATP production, potentially influencing Slc25a54's transport activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
An inhibitor of mitochondrial complex I that can decrease the proton gradient required for ATP synthesis, indirectly affecting Slc25a54 function. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
An inhibitor of mitochondrial complex III that can reduce ATP production, potentially influencing Slc25a54 activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glucose analog that can inhibit glycolysis and reduce ATP levels, potentially affecting ATP-dependent transport mechanisms involving Slc25a54. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
An inhibitor of mitochondrial complex IV that can disrupt the electron transport chain and ATP synthesis, potentially affecting Slc25a54 function. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
A protonophore that uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial membrane, potentially affecting Slc25a54. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
A potassium ionophore that can disrupt mitochondrial membrane potential, potentially influencing Slc25a54 transport activity. | ||||||