4930443G12Rik Activators
Chemical activators of solute carrier family 25, member 54 (SLC25A54) have diverse modes of action that result in the activation of this protein. Calcium chloride and ionomycin, through their ability to increase intracellular calcium levels, can activate SLC25A54, as elevated calcium acts as a secondary messenger in various signaling pathways. Such an increase in calcium concentration within the cell can lead to the activation of calcium-sensitive proteins and pathways that are associated with SLC25A54 function. Similarly, A23187 (Calcimycin) operates as a calcium ionophore, which transports calcium ions across the cell membrane, leading to a rise in intracellular calcium levels and subsequent activation of calcium-dependent signaling mechanisms.
Zinc chloride, Manganese(II) chloride, and Magnesium chloride contribute their respective metal ions, which are essential for numerous cellular processes. Zinc ions provided by zinc chloride are known to be crucial cofactors for protein function, and hence can activate SLC25A54 by ensuring its proper conformation and function. Manganese and magnesium ions supplied by Manganese(II) chloride and Magnesium chloride, respectively, may also serve as activators or cofactors necessary for the optimal activity of SLC25A54. Furthermore, Forskolin and 8-Bromo-cAMP, by elevating cAMP levels, lead to the activation of protein kinase A (PKA), which can phosphorylate and thus regulate proteins in the signaling pathways involving SLC25A54. Phosphorylation events are also central to the actions of Phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), and both Okadaic Acid and Sodium Orthovanadate, which inhibit phosphatases leading to increased phosphorylation levels. These phosphorylation events can result in the modulation of SLC25A54 activity. Lastly, Thapsigargin triggers the activation of SLC25A54 by depleting endoplasmic reticulum calcium stores, a process that activates calcium signaling cascades that may implicate SLC25A54.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride can activate solute carrier family 25, member 54 by increasing intracellular calcium, which is a secondary messenger known to activate various calcium-sensitive signaling pathways and proteins. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc chloride can activate solute carrier family 25, member 54 by providing zinc ions, which are essential cofactors for many proteins and may play a role in the proper function and activation of solute carrier proteins. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese(II) chloride can activate solute carrier family 25, member 54 by supplying manganese ions, which might serve as essential activators or cofactors for the protein or its associated pathways. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium chloride can activate solute carrier family 25, member 54 by contributing magnesium ions, which are crucial in many cellular processes including the activation of transport proteins. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate can activate solute carrier family 25, member 54 by inhibiting tyrosine phosphatases, which can lead to an increase in phosphorylation of proteins involved in the same pathway as the solute carrier. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin can activate solute carrier family 25, member 54 by increasing intracellular calcium concentration, thereby potentially activating calcium-dependent proteins and signaling cascades that solute carrier family 25, member 54 is a part of. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can activate solute carrier family 25, member 54 by activating PKC which could phosphorylate and activate proteins associated with the same signaling pathways as the solute carrier. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid can activate solute carrier family 25, member 54 by inhibiting phosphatases, which may lead to increased phosphorylation and activation of proteins within the solute carrier's pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin can activate solute carrier family 25, member 54 by depleting ER calcium stores and thereby activating calcium signaling mechanisms that the solute carrier is implicated in. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP can activate solute carrier family 25, member 54 by serving as a cAMP analog, leading to the activation of PKA and subsequent phosphorylation of associated proteins in the pathway. | ||||||