4930420K17Rik Activators
Chemical activators of transmembrane protein 243, mitochondrial, involve a diverse array of compounds that influence mitochondrial function through various mechanisms. Calcium ionophore A23187, by transporting Ca2+ ions, directly affects intracellular calcium levels, leading to the activation of this protein as a component of the calcium homeostasis process in mitochondria. Similarly, FCCP disrupts the proton gradient across the mitochondrial membrane, necessitating a response that includes the activation of transmembrane protein 243, mitochondrial, to restore the gradient and maintain mitochondrial function. The action of rotenone as a complex I inhibitor and antimycin A as a complex III inhibitor presents a stress to the mitochondrial electron transport chain, resulting in an increased need for regulatory mechanisms to sustain ATP production. The activation of transmembrane protein 243, mitochondrial, in these contexts, supports the continued function of the mitochondria amidst impaired electron transport.
Furthermore, oligomycin's inhibition of ATP synthase and valinomycin's disruption of potassium ion gradients both result in a compensatory increase in mitochondrial activity that involves the activation of transmembrane protein 243, mitochondrial. This protein's role is to aid in the stabilization of ATP levels and the mitochondrial membrane potential. CCCP similarly uncouples oxidative phosphorylation, leading to the activation of transmembrane protein 243, mitochondrial, as the mitochondria work to re-establish the proton gradient. In addition, agents like zinc pyrithione elevate intracellular zinc levels, engaging transmembrane protein 243, mitochondrial, in the maintenance of mitochondrial zinc homeostasis. Dinitrophenol, as a protonophore, necessitates an increase in metabolic rate to compensate for reduced ATP production efficiency, which in turn activates transmembrane protein 243, mitochondrial. Lastly, compounds such as nonylphenol and paraquat, which disrupt endocrine function and induce oxidative stress, respectively, can also lead to the activation of transmembrane protein 243, mitochondrial, as it responds to changes in mitochondrial dynamics and oxidative challenges to maintain the integrity of mitochondrial function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 directly increases intracellular calcium levels by transporting Ca2+ ions across cellular membranes. Elevated intracellular calcium can activate transmembrane protein 243, mitochondrial, as it is part of mitochondrial function and ion homeostasis, leading to its functional activation in maintaining calcium balance within the mitochondria. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP (carbonyl cyanide-p-trifluoromethoxyphenylhydrazone) dissipates the proton gradient across the mitochondrial membrane, which can lead to a compensatory increase in mitochondrial activity to restore the gradient. This compensatory response can include the activation of transmembrane protein 243, mitochondrial, to maintain mitochondrial function and membrane potential. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone, an inhibitor of mitochondrial complex I, can cause a buildup of NADH and a need for compensatory mechanisms to maintain cellular respiration. This stress on the mitochondria can activate transmembrane protein 243, mitochondrial, as part of the response to support continued ATP production and regulate electron transport chain activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits mitochondrial complex III, leading to reactive oxygen species (ROS) production and a drop in ATP synthesis. The increase in ROS and the need to maintain ATP production can activate transmembrane protein 243, mitochondrial, as it may play a role in responding to oxidative stress and helping to stabilize mitochondrial function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin binds to mitochondrial ATP synthase, inhibiting ATP production. This inhibition can result in a compensatory increase in mitochondrial activity, which may include the activation of transmembrane protein 243, mitochondrial, as the protein supports the restoration of ATP levels and mitochondrial membrane potential. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin acts as a potassium ionophore, disrupting potassium ion gradients. This disruption can activate transmembrane protein 243, mitochondrial, as part of the cellular response to re-establish ionic balance and maintain mitochondrial membrane potential. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP uncouples oxidative phosphorylation by transporting protons across the mitochondrial membrane, reducing the proton gradient and membrane potential. In response to this uncoupling, transmembrane protein 243, mitochondrial, can be activated to help re-establish the proton gradient and support mitochondrial function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can increase intracellular zinc levels, which may influence various cellular pathways including those in mitochondria. Elevated zinc levels can activate transmembrane protein 243, mitochondrial, by engaging in mitochondrial zinc homeostasis, thereby affecting mitochondrial function and dynamics. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
Dinitrophenol acts as a protonophore, facilitating proton leakage across the mitochondrial membrane, reducing ATP synthesis efficiency. This reduction can lead to an increased metabolic rate to compensate for decreased ATP production, which may activate transmembrane protein 243, mitochondrial, as part of the adaptive increase in mitochondrial function. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $149.00 | 7 | |
Paraquat induces oxidative stress by promoting the formation of superoxide radicals, particularly in mitochondria. This oxidative stress can lead to the activation of transmembrane protein 243, mitochondrial, as it may be involved in the cellular response to detoxify reactive oxygen species and maintain mitochondrial integrity. | ||||||