2900010M23Rik Inhibitors

Uqcc2 inhibitors encompass a range of compounds that indirectly impede the function of the ubiquinol-cytochrome c reductase complex assembly factor 2. These compounds do not target Uqcc2 directly but influence the mitochondrial electron transport chain (ETC), where Uqcc2 plays a role in the assembly and function of complex III. For example, inhibitors like Antimycin A and Stigmatellin bind to components of complex III, which Uqcc2 helps to assemble, thereby impairing its function indirectly. Similarly, Rotenone and Piericidin A disrupt complex I, which can lead to alterations in the ubiquinone pool-a critical component in the ETC that interacts with complex III. This can create an imbalanced environment that affects Uqcc2's role in complex III assembly.

Furthermore, other inhibitors, such as Thenoyltrifluoroacetone and Carboxin, target complex II, which is upstream of complex III in the ETC. Disrupting complex II affects the flow of electrons through the ETC and alters the reduction state of ubiquinone. Changes in the ubiquinone pool can, in turn, affect the assembly and stability of complex III, where Uqcc2 is involved. Inhibitors of complex IV, like Cyanide, Azide, and Carbon monoxide, and complex V, such as Oligomycin, exert their effects further downstream in the ETC. However, by disrupting the overall electron flow, these compounds can create an environment that can lead to feedback inhibition or compensatory responses that may indirectly influence the function of Uqcc2 in the assembly and maintenance of complex III.