2810408P10Rik Activators
Chemical activators of zinc finger protein 933 employ a variety of molecular mechanisms to enhance the protein's ability to bind to DNA and exert its function. Zinc Pyrithione utilizes the essentiality of zinc ions for the structural stability of zinc finger domains in zinc finger protein 933 by chelating zinc and facilitating its cellular uptake, thus directly increasing the intracellular concentration of zinc which is crucial for the protein's DNA-binding function. Trichostatin A, on the other hand, influences the chromatin architecture surrounding the DNA binding sites of the protein. By inhibiting histone deacetylases, Trichostatin A promotes a more open chromatin state, easing the access of zinc finger protein 933 to its DNA targets and facilitating its activation.
Further, compounds like Genistein, PD98059, LY294002, SB203580, and SP600125 modulate intracellular signaling pathways that indirectly enhance the activity of zinc finger protein 933. Genistein acts as a tyrosine kinase inhibitor, preventing negative regulatory phosphorylation events, which can enhance the DNA-binding activity of the protein. PD98059, an inhibitor of the MEK/ERK pathway, LY294002, a PI3K inhibitor, SB203580, a p38 MAP kinase inhibitor, and SP600125, a JNK signaling pathway inhibitor, all contribute to the activation of zinc finger protein 933 by interfering with phosphorylation-mediated inhibition, thereby promoting the protein's interaction with DNA. Additionally, Forskolin raises cAMP levels, activating Protein Kinase A, which may phosphorylate substrates that modulate the activity of zinc finger protein 933, leading to activation. Thapsigargin and PMA also activate the protein through kinase pathways; Thapsigargin increases intracellular calcium, potentially activating calcium-dependent kinases that modulate the protein's function, while PMA activates protein kinase C, which can phosphorylate regulatory proteins that interact with zinc finger protein 933, enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione can activate zinc finger protein 933 by chelating zinc ions and facilitating their cellular uptake. Zinc ions are essential for the structural stability of zinc finger domains in the protein, and their increased intracellular concentration can activate the DNA-binding function of zinc finger protein 933. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), which can result in a more open chromatin structure around the DNA-binding sites of zinc finger protein 933. This allows for easier access of the protein to its DNA targets, thereby enhancing its DNA-binding activity and functional activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can activate zinc finger protein 933 by inhibiting negative regulatory tyrosine phosphorylation events. By blocking such phosphorylation, Genistein may enhance the DNA-binding activity of zinc finger protein 933 as tyrosine phosphorylation can sometimes regulate protein-DNA interactions. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that can activate zinc finger protein 933 by reducing methylation levels of DNA. Hypomethylated DNA can lead to an increase in the binding of transcription factors, including zinc finger proteins, to their target gene promoters, thereby potentially enhancing the functional activity of zinc finger protein 933. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can activate zinc finger protein 933 by chelating metal ions such as copper and zinc, potentially increasing the availability of zinc for binding to the zinc finger motifs, which is critical for the structural integrity and function of zinc finger protein 933. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of the MEK/ERK pathway, which is involved in cell signaling. By inhibiting this pathway, PD98059 can activate zinc finger protein 933 through the alleviation of ERK-mediated phosphorylation that might otherwise suppress the DNA-binding activity of the protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can activate zinc finger protein 933 by altering intracellular signaling cascades, particularly those involved in the regulation of transcription factors. By inhibiting PI3K, LY294002 can lead to activation of zinc finger protein 933 through changes in its phosphorylation state, enhancing its ability to interact with DNA. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor which may activate zinc finger protein 933 by preventing the p38-mediated inhibitory phosphorylation, potentially enhancing the DNA-binding capacity and activation of the protein. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of the JNK signaling pathway, which can activate zinc finger protein 933 by reducing inhibitory phosphorylation events that may regulate the DNA-binding activity of zinc finger proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Increased intracellular calcium can activate calcium-dependent protein kinases, which in turn could activate zinc finger protein 933 by phosphorylating residues that regulate its DNA-binding activity. | ||||||