2810008M24Rik Inhibitors
The category of SMIM15 Inhibitors would include a diverse array of chemical compounds that indirectly affect the function of the small integral membrane protein 15 (SMIM15) by modulating the cellular and membrane-specific environment. This class of inhibitors does not target SMIM15 directly but influences the protein's activity by altering the structural and functional context within which the protein operates.
Compounds such as filipin III, amphotericin B, and nystatin interact with membrane sterols, altering the physical properties of cellular membranes, which could affect the localization and function of membrane proteins like SMIM15. Agents like methyl-β-cyclodextrin and U18666A alter cholesterol levels, which can disrupt membrane microdomains crucial for the function of many integral membrane proteins. Other compounds, such as genistein, act on signaling pathways and could affect SMIM15 indirectly by modifying the signaling environment. Disruptors of intracellular transport and structure, such as colchicine and dynasore, can also influence the localization and turnover of membrane proteins. Lastly, ionophores like monensin and ionomycin perturb ion gradients across the membrane, which can have diverse effects on membrane protein function by altering the ionic environment and signaling pathways.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Binds to sterols in cell membranes, potentially disrupting lipid rafts and membrane microdomains where SMIM15 may localize. | ||||||
Amphotericin B | 1397-89-3 | sc-202462 sc-202462A sc-202462B | 100 mg 500 mg 1 g | $69.00 $139.00 $219.00 | 10 | |
Interacts with ergosterol and forms pores in membranes, which can disrupt membrane integrity and protein function. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Modulates membrane fluidity and can displace membrane proteins from lipid rafts, potentially affecting SMIM15's localization or function. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Extracts cholesterol from membranes, disrupting lipid rafts and potentially SMIM15's membrane association. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Like amphotericin B, forms pores in membranes by binding to sterols, which could destabilize the membrane environment of SMIM15. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can alter cell signaling pathways, potentially affecting those associated with SMIM15. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
Cholesterol transport inhibitor that can disrupt intracellular cholesterol homeostasis and membrane composition. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
As a steroid, it can integrate into cell membranes and alter fluidity, which may affect the function of membrane proteins. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Disrupts microtubule polymerization, which can affect intracellular transport and localization of membrane proteins. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
A carboxylic ionophore that alters ion gradients and pH, which can impact membrane protein function. | ||||||