2310065K24Rik Inhibitors
Chemical inhibitors of 2310065K24Rik employ various mechanisms to modulate the activity of this protein by targeting different signaling molecules and pathways. Wortmannin and LY294002 are both inhibitors of phosphoinositide 3-kinases (PI3K), enzymes that play a critical role in cell growth and survival signaling. These inhibitors can halt the phosphorylation process that PI3K regulates, thereby leading to the inactivation of downstream proteins, including 2310065K24Rik, by preventing the necessary signaling events required for its activity. Similarly, U0126 and PD98059 are selective for MEK1/2, which are upstream regulators of the ERK pathway. The inhibition of MEK by these chemicals results in the blockade of ERK pathway activation, which may be essential for 2310065K24Rik function. This disruption in the signaling cascade can lead to reduced activity of 2310065K24Rik due to insufficient activation signals.
Further, SB203580 targets the p38 MAP kinase, another pathway integral to cellular responses to stress and inflammation. By inhibiting p38 MAP kinase, SB203580 can interfere with the cellular processes that possibly involve 2310065K24Rik, leading to a decrease in its activity. SP600125 functions by obstructing the c-Jun N-terminal kinase (JNK) pathway, which when inhibited, can affect the phosphorylation and thus the activity of proteins regulated by this pathway, potentially including 2310065K24Rik. Src family tyrosine kinases, which are implicated in various cellular processes, are inhibited by Dasatinib. This inhibition can affect 2310065K24Rik activity by preventing necessary phosphorylation events. Imatinib, Sorafenib, Sunitinib, Erlotinib, and Gefitinib are inhibitors that target a range of kinases, including BCR-ABL, c-Kit, PDGFR, RAF kinases, VEGFR, and EGFR. The inhibition of these kinases interrupts the respective signaling pathways that are crucial for the activity of several proteins. If 2310065K24Rik is a downstream effector of these pathways, the inhibition of these kinases would result in a decrease in the functional activity of 2310065K24Rik due to the disruption of signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways. By inhibiting PI3K, this chemical can reduce the phosphorylation of downstream targets, which may include 2310065K24Rik, resulting in its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of PI3K, similar to Wortmannin, and it can prevent the kinase activity of PI3K, leading to a decrease in the activity of downstream proteins that rely on PI3K signaling for activation, including 2310065K24Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 specifically inhibits MEK1/2, which are upstream regulators of the ERK pathway. The inhibition of MEK prevents the activation of ERK, which could be crucial for the activation of 2310065K24Rik, thereby inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which, like U0126, leads to the inhibition of ERK pathway signaling. This can reduce the activation of proteins that are dependent on this pathway, potentially including 2310065K24Rik, thereby inhibiting its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase can disrupt signaling pathways that regulate cellular responses to stress and inflammation, which may be necessary for the function of 2310065K24Rik, thus inhibiting its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits the c-Jun N-terminal kinase (JNK) pathway. By inhibiting JNK, this chemical can prevent the phosphorylation of proteins that are regulated by this pathway, which could include 2310065K24Rik, leading to its inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family tyrosine kinase inhibitor. By inhibiting Src kinases, Dasatinib can affect multiple cellular pathways, potentially including those that involve 2310065K24Rik, leading to its functional inhibition by preventing necessary phosphorylation events. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib inhibits BCR-ABL, c-Kit, and PDGFR kinases. By targeting these kinases, Imatinib can inhibit signaling pathways that are essential for the activity of downstream proteins, which may include 2310065K24Rik, thus leading to its inhibition. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a multikinase inhibitor that targets RAF kinases, VEGFR, and PDGFR. The inhibition of these kinases can disrupt signaling pathways that regulate cell proliferation and angiogenesis, which may be involved in the functional activity of 2310065K24Rik, resulting in its inhibition. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib is an inhibitor of receptor tyrosine kinases including VEGFR, PDGFR, and KIT. By inhibiting these kinases, Sunitinib can prevent the signaling required for the function of proteins in these pathways, which may include 2310065K24Rik, therefore inhibiting its activity. | ||||||