2310065K24Rik Activators
BC027060 Activators comprise a diverse array of chemical compounds that indirectly enhance the functional activity of BC027060 through a variety of signaling pathways. For instance, Forskolin and IBMX elevate cAMP and cGMP levels, respectively, leading to the activation of PKA and inhibition of PDEs, which in turn may phosphorylate and enhance the interaction of BC027060 within its specific signaling pathways. Similarly, PMA activates PKC, which is implicated in cell proliferation and survival pathways that can phosphorylate and augment BC027060 function. Sildenafil and Zaprinast, by inhibiting PDE5, increase cGMP levels and subsequently activate PKG, which might play a role in the activation of BC027060 through phosphorylation of associated proteins.
EGCG, with its kinase modulating properties, might inhibit kinases that downregulate BC027060's regulators, thereby indirectly enhancing its activity. A23187 raises intracellular calcium levels, activating pathways where BC027060 could be enhanced by calmodulin-dependent kinases. LY294002 and SB203580, by inhibiting PI3K and p38 MAP kinase respectively, may shift cellular signaling in favor of pathways that enhance BC027060's functions. U0126's inhibition of MEK1/2 allows for the potential activation of alternative pathways that could indirectly enhance BC027060 activity. Lastly, Okadaic Acid, by inhibiting protein phosphatases PP1 and PP2A, may increase the phosphorylated state of proteins that interact with BC027060, thereby enhancing its activity. These diverse chemical activators, through their targeted effects on various signaling mechanisms, collectively contribute to the functional enhancement of BC027060 without necessitating direct activation or upregulation of its expression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases intracellular cAMP by preventing its degradation. Elevated cAMP levels can lead to the activation of PKA, potentially augmenting the activity of 2310065K24Rik through PKA-mediated phosphorylation events. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a polyphenol found in green tea, has been shown to inhibit various protein kinases. This inhibition can lead to altered phosphorylation patterns within cells, potentially enhancing the activity of 2310065K24Rik if it is regulated by one of these kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that directly activates PKA. By mimicking cAMP and activating PKA, it can enhance the activity of 2310065K24Rik through downstream phosphorylation events that may affect 2310065K24Rik's function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of various substrates that might interact with or modify the activity of 2310065K24Rik, thereby enhancing its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K. By inhibiting PI3K, it can modulate downstream AKT signaling. This modulation might result in the activation of pathways or processes that enhance the activity of 2310065K24Rik. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that activates sphingosine-1-phosphate receptors, leading to various cellular responses. Activation of these receptors can lead to downstream effects that enhance the activity of 2310065K24Rik. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, which could enhance the activity of 2310065K24Rik if it is regulated by calcium-dependent mechanisms. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. Inhibition of certain kinases can paradoxically enhance the activity of 2310065K24Rik by reducing competition or by lifting inhibition on pathways involving 2310065K24Rik. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is an HDAC inhibitor that leads to hyperacetylation of histones, affecting gene expression. This epigenetic modulation may enhance the activity of 2310065K24Rik by facilitating the transcription of genes encoding proteins that interact with or regulate 2310065K24Rik. | ||||||