20S Proteasome α5 Activators
20S Proteasome α5 Activators, as identified in this list, are primarily compounds that can influence the function or expression of the 20S Proteasome α5 subunit indirectly. Most of the compounds listed are proteasome inhibitors. While they inhibit proteasome activity, they can also induce compensatory cellular mechanisms that may lead to changes in proteasome composition, expression, or activity.
Proteasome inhibitors like MG132, Bortezomib, Carfilzomib, and Lactacystin are widely used in research. Their primary action is to block proteasome activity, leading to the accumulation of proteins within cells. This accumulation can trigger cellular stress responses and enhance the expression or activity of other components of the proteasome system as a compensatory mechanism. Natural compounds such as Withaferin A, Celastrol, and Curcumin have been shown to modulate various cellular pathways, including those involving the proteasome. Their effects on the proteasome are part of a broader influence on cellular homeostasis and stress responses.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
While primarily an inhibitor, MG132 can lead to compensatory mechanisms that enhance proteasome activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Another proteasome inhibitor, which may induce feedback mechanisms affecting proteasome composition and activity. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
A selective proteasome inhibitor, its effects could influence proteasome dynamics indirectly. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
An inhibitor of proteasome activity, potentially influencing proteasomal regulation and expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Known for its use in alcohol dependence, it can also affect proteasome function. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A natural compound that can modulate proteasome activity. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
A triterpene that affects multiple cellular pathways, potentially influencing proteasome activity. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
An oral proteasome inhibitor, its effects might impact proteasome dynamics. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Affects various cellular pathways, potentially influencing proteasome function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known for its broad biological activities, it may indirectly affect proteasome function. | ||||||