1700023E05Rik Activators
RAI1 Activators encompass a diverse array of chemical compounds that underpin the functional activity of RAI1 through distinct but interconnected signaling pathways. Resveratrol, by stimulating SIRT1, enhances RAI1 activity through deacetylation processes that are pivotal for RAI1's role in chromatin remodeling. Similarly, Retinoic Acid, by activating RARs, directly influences the DNA-binding capacity of RAI1, thus bolstering its role in transcriptional regulation. Forskolin and Rolipram, through their elevation of cAMP. RAI1 Activators are a suite of chemical compounds that enhance the functional activity of RAI1 through a variety of signaling pathways. Resveratrol works through the SIRT1 pathway to promote deacetylation of RAI1, key to its activation and role in chromatin remodeling. Retinoic Acid, by engaging RARs, influences the DNA-binding capacity of RAI1, enhancing its regulatory functions in transcription. Forskolin and Rolipram, by increasing intracellular cAMP levels, activate PKA, which is believed to phosphorylate factors that modulate RAI1's transcriptional activity.
Epigallocatechin Gallate and other HDAC inhibitors like Trichostatin A, Sodium Butyrate, VPA, and SAHA, relax chromatin structure by increasing histone acetylation, thereby enhancing RAI1's accessibility to DNA and its subsequent activity in gene expression regulation. Lithium indirectly upregulates RAI1 through GSK-3 inhibition and consequent activation of Wnt signaling pathways, which are crucial in neurodevelopment where RAI1 is a key player. Moreover, Spermidine supports RAI1's role in maintaining cellular homeostasis by inducing autophagy, a process that can indirectly boost RAI1 function by clearing misfolded proteins and cellular debris. Curcumin, through its inhibition of NF-κB, may lift repression off certain genes, potentially aiding in the enhancement of RAI1's transcriptional regulatory activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which has been shown to subsequently enhance the functional activity of RAI1, as RAI1 is a downstream effector in the SIRT1 signaling pathway. This activation leads to the deacetylation of RAI1, which is crucial for its full activation and function in chromatin remodeling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates the retinoic acid receptors (RARs), which can interact with the regulatory region of the 1700023E05Rik gene, leading to a conformational change in RAI1 that enhances its DNA-binding capacity, thus increasing RAI1's functional activity in transcription regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits class I histone deacetylases (HDACs), which are known to repress chromatin and reduce gene expression. By inhibiting HDACs, EGCG indirectly enhances RAI1's function in chromatin remodeling by allowing a more open chromatin state and facilitating transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium acts as a GSK-3 inhibitor, which leads to the activation of Wnt signaling. While RAI1 is not a direct component of the Wnt pathway, activated Wnt signaling can enhance the expression of genes involved in neurodevelopment, indirectly upregulating RAI1 activity as it is a crucial protein in this process. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor that promotes acetylation of histones, leading to a more relaxed chromatin structure and enhanced transcription of certain genes. This effect can increase RAI1's functional activity as it is involved in gene regulation and chromatin remodeling. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, another HDAC inhibitor, also promotes histone acetylation, thus enhancing the transcriptional activity of RAI1 by allowing a more accessible chromatin state which is necessary for RAI1 to exert its effects on gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Similar to other HDAC inhibitors, VPA increases histone acetylation, potentially enhancing RAI1's functional activity related to chromatin remodeling and transcription regulation by creating a more transcriptionally active chromatin environment. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to facilitate autophagy, a process in which RAI1 is indirectly involved. Enhanced autophagy can upregulate RAI1 activity by clearing cellular debris and misfolded proteins, thus maintaining cellular homeostasis which is beneficial for RAI1's functional roles. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is an NF-κB inhibitor. By inhibiting NF-κB, curcumin may reduce the repression of certain genes, potentially enhancing the functional activity of RAI1 in transcription regulation and chromatin structure maintenance. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
By inhibiting phosphodiesterase-4, Rolipram increases cAMP levels, similarly to forskolin, which can then activate PKA and potentially enhance the transcriptional regulation activity of RAI1 through PKA-mediated pathways. | ||||||