1700021F05Rik Activators
1700021F05Rik Activators are a collection of chemical entities that can indirectly augment the protein's functional activity by influencing various intracellular signaling pathways. Forskolin serves to elevate intracellular cAMP levels, leading to the activation of PKA, which may phosphorylate and thus influence the activity of substrates within the signaling cascades that 1700021F05Rik participates in. Genistein, through its action as a tyrosine kinase inhibitor, could diminish competitive signaling processes, potentially enhancing the activity of pathways that 1700021F05Rik is associated with. Lipid signaling is impacted by Sphingosine-1-phosphate, which could positively influence the activation of signaling cascades relevant to 1700021F05Rik's function. Additionally, Thapsigargin, by inhibiting SERCA, raises intracellular calcium levels, potentially activating calcium-dependent pathways that cross-talk with those involving 1700021F05Rik.
The modulation of kinase activity by compounds like PMA, LY294002, Wortmannin, and Epigallocatechin gallate (EGCG) also plays a critical role in the indirect activation of 1700021F05Rik. PMA, as a PKC activator, could potentiate the phosphorylation of proteins within 1700021F05Rik-related pathways, while PI3K inhibitors LY294002 and Wortmannin may shift signaling dynamics in a manner that favors those involving 1700021F05Rik. The MEK1/2 inhibitor U0126 and the p38 MAP kinase inhibitor SB203580 could likewise redirect signaling traffic towards 1700021F05Rik pathways by limiting the phosphorylation of competing substrates. A23187, a calcium ionophore, may enhance the activity of 1700021F05Rik by upregulating calcium-dependent signaling mechanisms. Further, Staurosporine, despite its broad kinase inhibition profile, could lead to selective activation of 1700021F05Rik pathways by alleviating the suppression exerted by certain kinases. Collectively, these activators, through targeted biochemical interactions, facilitate the enhancement of 1700021F05Rik's functional activity without directly increasing its expression or requiring direct activation of the protein itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, leading to increased cAMP and cGMP levels in cells. This would potentiate the activation of PKA or PKG, which could then phosphorylate Protein 1700021F05Rik or associated proteins, enhancing its activity indirectly through these signaling cascades. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of downstream proteins. If Protein 1700021F05Rik is a substrate for PKC or part of a pathway modulated by PKC, PMA can indirectly enhance its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent kinases such as calmodulin-dependent kinase (CaMK). If Protein 1700021F05Rik is regulated by calcium signaling or CaMK, ionomycin may enhance its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) binds to and activates S1P receptors, which are coupled to G-protein signaling pathways. This can lead to downstream activation of MAPK, PI3K/Akt, and PLC pathways. If Protein 1700021F05Rik activity is modulated by any of these pathways, S1P can serve as an indirect activator. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, which could lead to decreased competition in phosphorylation signaling pathways. If Protein 1700021F05Rik is regulated by a kinase that is inhibited by EGCG, this could result in a relative increase in Protein 1700021F05Rik phosphorylation and activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to alterations in the PI3K/Akt pathway. If Protein 1700021F05Rik is activated by PI3K signaling or downstream effects of Akt, inhibition of this pathway may paradoxically enhance the activity of Protein 1700021F05Rik by reducing negative feedback or altering pathway dynamics. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can modulate the cellular stress response and may enhance the activity of Protein 1700021F05Rik if it is involved in parallel signaling pathways or if p38 MAPK exerts inhibitory effects on pathways that activate Protein 1700021F05Rik. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, similar to ionomycin. This can activate calcium-dependent signaling pathways. If Protein 1700021F05Rik is responsive to changes in calcium signaling, A23187 may indirectly enhance its activity. | ||||||