1700020N15Rik Inhibitors
Chemical inhibitors of 1700020N15Rik act predominantly through the interruption of vital signaling pathways and cell cycle regulation mechanisms that are essential for the protein's function. Palbociclib and its alternative name, PD0332991, are selective inhibitors targeting the cyclin-dependent kinases CDK4 and CDK6. These kinases play a crucial role in the progression of the cell cycle, and their inhibition directly prevents the advancement of the cell cycle phases, wherein 1700020N15Rik is active. Similarly, other chemicals like Omipalisib, AZD8055, and Torin 1, focus on the PI3K/mTOR pathways, which are intricately related to the activities and regulation of 1700020N15Rik. Omipalisib, serving as a dual PI3K/mTOR inhibitor, and AZD8055 and Torin 1, as mTOR specific inhibitors, all lead to the disruption of the downstream signaling necessary for 1700020N15Rik's activity within cellular processes.
Moreover, compounds such as PP242, KU-0063794, and WYE-125132, which are also mTOR inhibitors, function by obstructing the kinase activity of mTOR. This action effectively hampers the signaling pathways that 1700020N15Rik is a part of, thereby inhibiting the protein's function. Rapamycin, another mTOR pathway inhibitor, employs a slightly different approach by forming a complex with FKBP12 that specifically inhibits mTORC1, a complex that is vital for mTOR pathway signaling and 1700020N15Rik's role within it. AZD2014 extends this inhibition to both mTORC1 and mTORC2 complexes, which are essential for proper signaling and function of 1700020N15Rik. GSK2126458, with its high selectivity towards PI3K and mTOR, and OSI-027, a dual mTORC1 and mTORC2 inhibitor, likewise inhibit the necessary signaling pathways, ensuring the functional inhibition of 1700020N15Rik. Each of these chemicals, through their targeted actions, ensures that the critical pathways and processes that 1700020N15Rik is involved in are effectively disrupted, leading to the inhibition of its function within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Since 1700020N15Rik is involved in cell cycle regulation, inhibition of CDK4/6 by Palbociclib could prevent the progression of the cell cycle, thereby functionally inhibiting 1700020N15Rik by blocking its associated processes. | ||||||
PD 0332991 Isethionate | 827022-33-3 | sc-478943 | 1 mg | $300.00 | ||
PD0332991, also known as Palbociclib, inhibits CDK4/6 activity. By doing so, it can inhibit the cell cycle progression and functionally inhibit 1700020N15Rik by halting the cellular processes it is involved in. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
Omipalisib is a PI3K/mTOR inhibitor. Since 1700020N15Rik is implicated in signaling pathways that may intersect with PI3K/mTOR pathways, Omipalisib can inhibit these pathways, leading to a functional inhibition of 1700020N15Rik by impairing the signaling required for its activity. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is a potent inhibitor of mTOR, which is a component of the PI3K/AKT/mTOR pathway. Inhibition of mTOR can lead to a functional inhibition of 1700020N15Rik by disrupting the downstream signaling events in which 1700020N15Rik is involved. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an mTOR inhibitor that can block the activity of mTORC1 and mTORC2 complexes. Inhibiting these complexes could functionally inhibit 1700020N15Rik by impeding the mTOR signaling pathway, which plays a role in the regulation of the protein's function. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective inhibitor of mTOR kinase activity. By inhibiting mTOR, PP242 can functionally inhibit 1700020N15Rik by obstructing the signaling pathways necessary for its activity within the cell. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
KU-0063794 directly inhibits mTORC1 and mTORC2 complexes. Through this inhibition, KU-0063794 can functionally inhibit 1700020N15Rik by disrupting the pathways that regulate its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a well-known inhibitor of the mTOR pathway. It binds to FKBP12 and the resulting complex inhibits mTORC1. This inhibition can functionally inhibit 1700020N15Rik by impairing the mTOR pathway which is crucial for its activity. | ||||||
AZD2014 | 1009298-59-2 | sc-364420 | 5 mg | $303.00 | 2 | |
AZD2014 is a selective inhibitor of mTORC1 and mTORC2. Inhibition of these complexes can functionally inhibit 1700020N15Rik by impeding the mTOR signaling pathway, thus affecting the protein's function. | ||||||
GSK2126458 | 1086062-66-9 | sc-364503 sc-364503A | 2 mg 10 mg | $260.00 $1029.00 | ||
GSK2126458 is a potent and highly selective inhibitor of PI3K and mTOR. By inhibiting these kinases, GSK2126458 can functionally inhibit 1700020N15Rik by blocking the signaling pathways that are essential for its activity. | ||||||