1700018C11Rik Inhibitors
Chemical inhibitors of protein 1700018C11Rik employ various mechanisms to modulate its activity. Staurosporine, a broad-spectrum kinase inhibitor, targets the phosphorylation process, which is a common regulatory mechanism for many proteins. By inhibiting kinase activity, Staurosporine can alter the phosphorylation state of protein 1700018C11Rik, which may be crucial for its functional conformation or interaction with other cellular components. Similarly, LY294002 and Wortmannin are both inhibitors of PI3K, an upstream regulator of the Akt signaling pathway. Inhibition of PI3K leads to a reduction in Akt pathway signaling, which can affect numerous downstream proteins and processes. If protein 1700018C11Rik is part of or regulated by this pathway, its activity can be affected by these inhibitors.
Furthermore, U0126 and PD98059 are specific inhibitors of MEK, another kinase involved in the ERK/MAPK signaling pathway. By preventing MEK from phosphorylating ERK, these inhibitors can disrupt the signaling cascade that may be necessary for the function of protein 1700018C11Rik. SB203580, on the other hand, targets the p38 MAP kinase, which is implicated in the response to stress stimuli. Protein 1700018C11Rik can be influenced by alterations in stress response pathways mediated by p38 MAP kinase inhibition. Rapamycin, an mTOR inhibitor, can decrease the overall protein synthesis and affect the function of downstream proteins regulated by mTOR, which may include protein 1700018C11Rik. Bortezomib's action on the 26S proteasome can lead to the accumulation of proteins targeted for degradation, altering the protein homeostasis within the cell and potentially affecting protein 1700018C11Rik.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent kinase inhibitor that may inhibit the phosphorylation state of 1700018C11Rik if it is a kinase-dependent protein, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, potentially reducing Akt pathway signaling which might be necessary for the activation or stabilization of 1700018C11Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Similar to LY294002, Wortmannin is a PI3K inhibitor that could lead to a decrease in phosphorylation and activation of downstream targets that may be required for 1700018C11Rik function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK, which could prevent the ERK/MAPK pathway's phosphorylation, potentially necessary for 1700018C11Rik's activity if it's part of this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This compound inhibits p38 MAP kinase potentially impacting stress response pathways that might be necessary for 1700018C11Rik's function if it is involved in such signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an MEK inhibitor which may block ERK pathway signaling potentially affecting the activity of 1700018C11Rik if it's reliant on this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which could lead to reduced protein synthesis and function of proteins that are downstream or regulated by mTOR, possibly including 1700018C11Rik. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits the 26S proteasome, potentially leading to increased cellular stress and inhibition of proteins that are regulated by proteasomal degradation, including putatively 1700018C11Rik. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, possibly impacting the NFAT pathway and could inhibit the function of 1700018C11Rik if it is regulated by or interacts with components of this pathway. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) leading to disruption of calcium homeostasis, which could inhibit 1700018C11Rik if calcium signaling regulates its function. | ||||||