1700013D24Rik Activators
1700013D24Rik Activators encompass a variety of chemical compounds that contribute to the functional enhancement of the 1700013D24Rik protein through diverse signaling mechanisms. Compounds such as Forskolin and Dibutyryl-cAMP enhance 1700013D24Rik function by increasing intracellular cAMP levels, subsequently activating PKA, which may phosphorylate and activate proteins within the 1700013D24Rik pathway. Akt1 activators encompass a collection of chemical entities that, through various mechanisms, enhance the activation state of Akt1, a serine/threonine-specific protein kinase that plays a critical role in multiple cellular processes, including metabolism, proliferation, cell survival, growth, and angiogenesis. Small-molecule activators such as SC79 directly interact with Akt1, binding to its pleckstrin homology (PH) domain, which aids in the kinase's translocation to the plasma membrane where it becomes fully active following phosphorylation. Natural compounds like Resveratrol and Curcumin are known to exert effects on AMPK and PI3K/Akt pathways, respectively, leading to a secondary upregulation of Akt1 activity. Hormonal activators, such as Insulin and IGF-1, exert their effects through receptor-mediated processes, initiating signaling cascades that culminate in the phosphorylation and activation of Akt1. Similarly, growth factors like PDGF and EGF, upon binding to their respective receptors, trigger downstream PI3K/Akt signaling, resulting in enhanced Akt1 kinase activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, potentially leading to the enhancement of the 1700013D24Rik protein's function if it is calcium-sensitive. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins involved in the signaling pathways of 1700013D24Rik, thereby enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit certain kinases. This inhibition may reduce negative regulatory pathways, leading to an enhancement of 1700013D24Rik activity if these kinases are involved in its inactivation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling pathways downstream of PI3K, potentially leading to the activation of 1700013D24Rik by altering the balance of signaling molecules. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore, similar to Ionomycin, which increases intracellular calcium levels and could potentiate the activity of 1700013D24Rik through calcium-dependent signaling pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a phosphatase inhibitor that can enhance tyrosine phosphorylation levels by inhibiting their dephosphorylation, potentially increasing the activity of 1700013D24Rik if it is regulated by tyrosine phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA, leading to the enhancement of 1700013D24Rik activity through cAMP-dependent pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors and may lead to the enhancement of 1700013D24Rik activity through alterations in cell survival and proliferation signaling. | ||||||