Date published: 2026-4-5

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15-LO Inhibitors

15-LO inhibitors represent a diverse group of chemical compounds that primarily target the 15-lipoxygenase (15-LO) enzyme, interfering with its biochemical functions. The primary role of 15-LO is to oxidize polyunsaturated fatty acids, such as arachidonic acid, to produce various bioactive lipid mediators. These lipid mediators are often implicated in a range of physiological and pathophysiological processes like inflammation, immune responses, and cell differentiation. Compounds that serve as 15-LO inhibitors may act through various mechanisms, such as by directly binding to the enzyme's active site, competing with the substrate, or downregulating the expression of the enzyme at the mRNA level. These compounds often exhibit their inhibitory effects by diminishing the enzymes ability to form its typical end products, such as 15-hydroxyeicosatetraenoic acid (15-HETE).The chemical diversity among 15-LO inhibitors is substantial, encompassing flavonoids like quercetin and kaempferol, polyphenols like resveratrol and curcumin, and synthetic compounds like zileuton. These molecules may be found in various sources, including plants, fungi, and synthetic pathways. Despite their varied origins, they generally share the common feature of mitigating 15-LO's enzymatic activity to some extent. Factors like chemical structure, functional groups, and other physicochemical properties can influence the affinity and effectiveness of these inhibitors towards 15-LO. Studies often use techniques like enzymatic assays, molecular docking, and gene expression analysis to understand the mechanisms through which these compounds exert their inhibitory effects on 15-LO.

Items 11 to 20 of 20 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

CDC

132465-11-3sc-200562
sc-200562A
10 mg
50 mg
$75.00
$309.00
1
(1)

CDC acts as a potent modulator of 15-lipoxygenase, showcasing a distinctive ability to engage in non-covalent interactions with the enzyme's active site. This compound influences the enzyme's reaction kinetics by stabilizing intermediate states, thereby altering the rate of substrate conversion. Its unique structural attributes enable selective binding, which can lead to significant changes in lipid-derived signaling molecules, impacting various biological processes.

Zileuton

111406-87-2sc-204417
sc-204417A
sc-204417B
sc-204417C
10 mg
50 mg
1 g
75 g
$84.00
$307.00
$369.00
$1254.00
8
(1)

Zileuton is known to selectively inhibit 15-LO, interfering with the conversion of arachidonic acid into bioactive lipids.

9,12-Octadecadiynoic Acid

2012-14-8sc-205191
sc-205191A
1 mg
5 mg
$80.00
$360.00
(0)

9,12-Octadecadiynoic Acid exhibits remarkable properties as a 15-lipoxygenase modulator, characterized by its ability to form unique hydrogen bonds and hydrophobic interactions with the enzyme. This compound alters the enzyme's catalytic efficiency by promoting specific conformational changes, which can enhance or inhibit substrate access. Its distinct acetylenic structure allows for selective interactions, influencing lipid metabolism and downstream signaling pathways in intricate ways.

Myricetin

529-44-2sc-203147
sc-203147A
sc-203147B
sc-203147C
sc-203147D
25 mg
100 mg
1 g
25 g
100 g
$97.00
$188.00
$260.00
$510.00
$1022.00
3
(1)

Myricetin is believed to suppress 15-LO by binding to its active site, thereby inhibiting the conversion of polyunsaturated fatty acids into lipid mediators.

15-Lipoxygenase Inhibitor I

928853-86-5sc-220625
sc-220625A
500 µg
1 mg
$35.00
$65.00
(0)

15-Lipoxygenase Inhibitor I is a potent modulator of the 15-lipoxygenase enzyme, distinguished by its ability to engage in specific electrostatic interactions that stabilize enzyme-substrate complexes. This compound influences the enzyme's reaction kinetics by altering the transition state, thereby affecting the rate of lipid peroxidation. Its unique structural features facilitate selective binding, leading to modulation of lipid-derived signaling pathways and cellular responses.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol is thought to inhibit 15-LO expression by downregulating its mRNA levels, thereby reducing its enzymatic activity.

Caffeic Acid

331-39-5sc-200499
sc-200499A
1 g
5 g
$32.00
$62.00
1
(2)

Caffeic Acid inhibits the enzymatic activity of 15-LO by occupying its active site, which results in reduced formation of lipid mediators.

Kaempferol

520-18-3sc-202679
sc-202679A
sc-202679B
25 mg
100 mg
1 g
$99.00
$216.00
$510.00
11
(1)

Kaempferol inhibits the enzymatic activity of 15-LO by binding to its active site, preventing the formation of bioactive lipids.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein is thought to downregulate the expression of 15-LO at the mRNA level, which in turn reduces its enzymatic activity.

Apigenin

520-36-5sc-3529
sc-3529A
sc-3529B
sc-3529C
sc-3529D
sc-3529E
sc-3529F
5 mg
100 mg
1 g
5 g
25 g
100 g
1 kg
$33.00
$214.00
$734.00
$1151.00
$2348.00
$3127.00
$5208.00
22
(1)

Apigenin is known to inhibit 15-LO by interacting with its active site, thereby reducing its enzymatic activity and the formation of lipid mediators.