Molecular structure of CDC, CAS Number: 132465-11-3
CDC (CAS 132465-11-3)
See product citations (1)
Application:
CDC is an inhibitor of 5-LO, 12-LO, and 15-LO
CAS Number:
132465-11-3
Purity:
≥98%
Molecular Weight:
321.3
Molecular Formula:
C19H15NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
CDC is a metabolite of ciproflaxacin and is a selective 12-LO (12-lipoxygenase) inhibitor. CDC also inhibits 5-LO and 15-LO.
CDC (CAS 132465-11-3) References
- Lipoxygenase-dependent mechanisms in hypertension. | DelliPizzi, A., et al. 2000. Clin Exp Hypertens. 22: 181-92. PMID: 10744358
- Lipoxygenase-dependent superoxide release in skeletal muscle. | Zuo, L., et al. 2004. J Appl Physiol (1985). 97: 661-8. PMID: 15107407
- 12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat. | Ma, J., et al. 2005. Prostaglandins Leukot Essent Fatty Acids. 72: 13-20. PMID: 15589395
- Properties of BK(Ca) channels in oral keratinocytes. | Shieh, DB., et al. 2005. J Dent Res. 84: 468-73. PMID: 15840785
- Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. | Kälvegren, H., et al. 2007. Eur J Pharmacol. 566: 20-7. PMID: 17459368
- Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. | Gong, YZ., et al. 2008. Eur J Pharmacol. 600: 18-25. PMID: 18930721
- A 4-oxo-2(E)-nonenal-derived glutathione adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid. | Zhu, P., et al. 2009. Free Radic Biol Med. 47: 953-61. PMID: 19576981
- Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase. | Cho, H., et al. 1991. J Med Chem. 34: 1503-5. PMID: 2016727
- Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase. | Pergola, C., et al. 2011. J Pharmacol Exp Ther. 338: 205-13. PMID: 21447614
- Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function. | Svensson Holm, AC., et al. 2014. Platelets. 25: 111-7. PMID: 23534390
- Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1 Channels. | Ma, R. and Lewis, A. 2020. Front Pharmacol. 11: 434. PMID: 32317978
- Pharmacological characterization of the biosynthesis of prostanoids and hydroxyeicosatetraenoic acids in human whole blood and platelets by targeted chiral lipidomics analysis. | Tacconelli, S., et al. 2020. Biochim Biophys Acta Mol Cell Biol Lipids. 1865: 158804. PMID: 32853794
- Prostaglandin I2 contributes to the vasodepressor effect of baicalein in hypertensive rats. | Takizawa, H., et al. 1998. Hypertension. 31: 866-71. PMID: 9495274
Inhibitor of:
12-LO, 15-LO, and 5-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDC, 10 mg | sc-200562 | 10 mg | $75.00 | |||
CDC, 50 mg | sc-200562A | 50 mg | $309.00 |