1110037F02Rik Inhibitors
Chemical inhibitors of the protein 1110037F02Rik function through various mechanisms to disrupt the signaling pathways that regulate its activity. Staurosporine, a broad-spectrum kinase inhibitor, prevents the phosphorylation of kinases that are crucial for the activation of 1110037F02Rik, leading to its functional inhibition. Similarly, Bisindolylmaleimide I, by specifically targeting protein kinase C, disrupts the phosphorylation cascade essential for 1110037F02Rik's function. LY294002 and Wortmannin, both phosphoinositide 3-kinases (PI3K) inhibitors, obstruct the PI3K pathway, thereby preventing the activation of downstream targets necessary for 1110037F02Rik's activity. Rapamycin's inhibition of the mammalian target of rapamycin (mTOR) interferes with key regulatory processes, including the protein synthesis that 1110037F02Rik depends on.
In the MAPK pathway, U0126 and PD98059 target MEK1/2, inhibiting the subsequent activation of ERK1/2 kinases, which are likely upstream regulators of 1110037F02Rik, resulting in its functional inhibition. SB203580 operates by selectively inhibiting p38 MAP kinase, which is implicated in the stress response and cytokine signaling that may modulate 1110037F02Rik's activity. SP600125's inhibition of c-Jun N-terminal kinase (JNK) suppresses gene expression and cell fate pathways that 1110037F02Rik is part of. Dasatinib, as a broad-spectrum tyrosine kinase inhibitor, can impede the function of kinases like BCR-ABL and the Src family, which are involved in the regulation of 1110037F02Rik. Lapatinib's dual inhibition of EGFR and HER2/neu leads to the obstruction of downstream signaling such as the PI3K/AKT pathway, which is integral for 1110037F02Rik's functionality. Lastly, PP2 inhibits Src family tyrosine kinases, whose activity is necessary for the proper function of 1110037F02Rik. Each inhibitor, by targeting specific molecules within these pathways, contributes to the overall suppression of 1110037F02Rik's activity in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. While it targets a broad range of kinases, its action can inhibit the kinase-dependent activation of 1110037F02Rik, leading to a functional inhibition of this protein's activity within cellular signaling pathways. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I, also known as GF 109203X, is a specific inhibitor of protein kinase C (PKC). By inhibiting PKC, it disrupts the phosphorylation and activation of downstream proteins that are critical for the function of 1110037F02Rik, thereby inhibiting its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a selective inhibitor of phosphoinositide 3-kinases (PI3K). It prevents PI3K from phosphorylating and activating downstream targets, which are necessary for the proper functioning of 1110037F02Rik. As a result, the inhibition of this pathway leads to the functional inhibition of 1110037F02Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that binds covalently to the catalytic site of the enzyme, blocking its activity. This inhibition results in the suppression of PI3K-dependent signaling pathways, which are essential for the functional activity of 1110037F02Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically inhibits the mammalian target of rapamycin (mTOR), a key regulatory kinase. Since mTOR is involved in the control of protein synthesis and cell growth, its inhibition by Rapamycin can lead to reduced activity of 1110037F02Rik by hindering the protein synthesis machinery or signaling pathways that are required for its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), a part of the MAPK/ERK pathway. By inhibiting MEK1/2, U0126 prevents the activation of ERK1/2 kinases, which could be upstream regulators or interact with signaling pathways involving 1110037F02Rik, thus leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which blocks the activation of the downstream kinase ERK. By doing so, it hinders the signaling pathways that rely on ERK's kinase activity, which includes the functional activation of 1110037F02Rik, leading to its inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase, which is involved in the response to stress signals and cytokines. As p38 MAP kinase plays a role in signaling cascades that could regulate the activity of 1110037F02Rik, its inhibition by SB203580 can lead to the functional inhibition of 1110037F02Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which participates in signaling pathways controlling gene expression and cell fate. By inhibiting JNK, SP600125 can suppress the pathways that are necessary for the functional activity of 1110037F02Rik, thus functionally inhibiting the protein. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor that can interfere with the BCR-ABL kinase and Src family kinases. It can functionally inhibit 1110037F02Rik by inhibiting tyrosine kinases that are involved in the signaling pathways regulating 1110037F02Rik's activity. | ||||||