1110020G09Rik Activators
1110020G09Rik Activators encompass a suite of chemical compounds that facilitate the augmentation of the protein's activity through a variety of signaling pathways and cellular processes. Forskolin, by elevating cAMP, indirectly activates PKA, which can phosphorylate proteins involved in the same pathways as 1110020G09Rik, thereby enhancing its activity. Similarly, IBMX increases cAMP levels, leading to a cascade of events that bolster PKA activity and, consequently, the functional role of 1110020G09Rik. PMA's activation of PKC and Epigallocatechin gallate's inhibition of competitive protein kinases provide a conducive environment for 1110020G09Rik activity by modulating signaling pathways. Similarly, lipid signaling modulated by Sphingosine-1-phosphate and the elevation of intracellular calcium levels by Thapsigargin both potentiate the activity of 1110020G09Rik by impacting membrane dynamics and calcium-dependent signaling cascades. PMA's activation of PKC and EGCG's inhibition of competitive kinases offer additional routes through which 1110020G09Rik's functions may be enhanced. The activity of PI3K inhibitors, LY294002 and Wortmannin, shifts the intracellular signaling milieu, possibly favoring pathways that 1110020G09Rik is a part of, thus enhancing its activity.
Additionally, the functional activity of 1110020G09Rik is influenced by compounds that modulate MAPK signaling. SB203580 and U0126, which inhibitp38 and MEK1/2 respectively, may shift signaling towards 1110020G09Rik's pathways, leading to enhanced activity. This is a strategic redirection of signaling traffic away from competing pathways, bolstering those in which 1110020G09Rik operates. The ionophore A23187 raises intracellular calcium levels, thus potentially facilitating 1110020G09Rik activation through calcium-dependent pathways that are integral to its function. Staurosporine, although a broad kinase inhibitor, may paradoxically upregulate 1110020G09Rik activity by inhibiting kinases that otherwise suppress pathways associated with 1110020G09Rik.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that can inhibit certain protein kinases, thereby potentially altering signaling cascades that indirectly increase the functional activity of 1110020G09Rik by reducing competitive signaling that may otherwise attenuate its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which increases intracellular cAMP levels, similarly activating PKA and enhancing the pathways where 1110020G09Rik is operative. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC) which is involved in numerous signaling pathways. Activation of PKC can lead to the enhanced activity of 1110020G09Rik by modulating cellular processes that the protein is involved in. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to activate intracellular signaling pathways, such as PI3K/Akt, which could enhance the functional activity of 1110020G09Rik by influencing the cellular environment that it operates within. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter the PI3K/Akt pathway, indirectly enhancing the activity of 1110020G09Rik by modulating a pathway that it is involved in, possibly by reducing negative regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways and thereby enhance the functional activity of 1110020G09Rik. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor which could lead to the indirect activation of 1110020G09Rik by inhibiting kinases that negatively regulate pathways where 1110020G09Rik is active. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which by inhibiting competitive signaling pathways could indirectly enhance the activity of 1110020G09Rik by allowing for less attenuated signaling through pathways the protein is involved in. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase which may indirectly enhance the functional activity of 1110020G09Rik by altering the dynamics of the signaling pathways where the protein participates. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can change the PI3K/Akt pathway dynamics, potentially leading to an enhancement of the activity of 1110020G09Rik by modulating the signaling environment. | ||||||