TCR V γ 3 Inhibitors
TCR V γ 3 inhibitors are a collection of chemical compounds that decrease the functional activity of the TCR V γ 3 protein. Inhibitors like Cyclosporin A and FK506 function by suppressing the dephosphorylation of NFAT, a key factor in T-cell activation. By preventing NFAT from translocating to the nucleus, these inhibitors disrupt the transcription of genes involved in this activation process, including TCR V γ 3. This action effectively reduces the functional activity of the TCR V γ 3 protein. Similarly, Rapamycin, an mTOR inhibitor, blocks mTOR signaling, a pathway critical for T-cell activation. This action leads to decreased functional activity of the TCR V γ 3 protein.
Glucocorticoids such as Dexamethasone, Prednisolone, and Hydrocortisone inhibit the production of pro-inflammatory cytokines, which are essential for T-cell activation. By suppressing these cytokines, these glucocorticoids can decrease the functional activity of TCR V γ 3. Immunosuppressants like Ascomycin and Azathioprine, and inhibitors like Mycophenolic Acid and Methotrexate, disrupt critical processes in T-cell activation, which in turn reduces the functional activity of TCR V γ 3. Specifically, Ascomycin inhibits calcineurin, Mycophenolic Acid inhibits inosine monophosphate dehydrogenase, and Methotrexate inhibits dihydrofolate reductase. Eachof these inhibitors impacts a different aspect of T-cell activation, leading to decreased functional activity of TCR V γ 3.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 is a calcineurin inhibitor that can also prevent the dephosphorylation of NFAT, disrupting T-cell activation and the functional activity of TCR V γ 3. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can inhibit the production of pro-inflammatory cytokines, leading to decreased T-cell activation and functional activity of TCR V γ 3. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $84.00 $253.00 | 2 | |
Prednisolone is a glucocorticoid that can also inhibit the production of pro-inflammatory cytokines, decreasing T-cell activation and functional activity of TCR V γ 3. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone is a glucocorticoid that can inhibit the production of pro-inflammatory cytokines, reducing T-cell activation and functional activity of TCR V γ 3. | ||||||
Ascomycin | 104987-12-4 | sc-207303B sc-207303 sc-207303A | 1 mg 5 mg 25 mg | $37.00 $176.00 $322.00 | ||
Ascomycin is an immunosuppressant that can inhibit T-cell activation by blocking calcineurin, leading to decreased functional activity of TCR V γ 3. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic Acid inhibits inosine monophosphate dehydrogenase, leading to a decrease in guanosine nucleotides and suppressing T-cell activation and the functional activity of TCR V γ 3. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine is an immunosuppressive agent that can inhibit purine synthesis, leading to decreased T-cell activation and functional activity of TCR V γ 3. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is an inhibitor of thioredoxin reductase, which can disrupt redox balance in T-cells, leading to decreased functional activity of TCR V γ 3. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is an inhibitor of dihydrofolate reductase, which can inhibit the synthesis of purine and pyrimidine, leading to decreased T-cell activation and functional activity of TCR V γ 3. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide is a pyrimidine synthesis inhibitor, which can decrease T-cell activation and the functional activity of TCR V γ 3. | ||||||