TCR V γ 3 Antibody (536): sc-53027
- TCR V γ 3 Antibody (536) is a Syrian hamster monoclonal IgG TCR V γ 3 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against residues common to the C-termini of TCR V γ 3 of mouse origin
- TCR V gamma 3 Antibody (536) is recommended for detection of variable region of TCR V γ 3 of mouse origin by IP, IF, IHC(P) and FCM
- Anti-TCR V gamma 3 Antibody (536) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCR V γ 3 Antibody (536). This work is in progress.
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TCR V γ 3 Antibody (536) is a hamster monoclonal IgG antibody that detects TCR V gamma 3 protein of mouse origin by immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). Anti-TCR V γ 3 antibody (536) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing a diverse array of foreign antigens, which is essential for the activation of T cells and the subsequent immune response. The TCR is a heterodimer that can be composed of either alpha and beta or gamma and delta chains, with the majority of T cells (approximately 95%) expressing the alpha/beta heterodimer, while a smaller subset (about 2-5%) expresses the gamma/delta heterodimer. The ability of TCRs to recognize a wide variety of antigens is achieved through the somatic recombination of variable (V), diversity (D), and joining (J) gene segments during TCR chain assembly. The TCR gamma chain is unique in that it is composed solely of V and J segments, which allows for a streamlined process of generating diverse TCRs. Understanding the structure and function of TCRs, including TCR V gamma 3, is vital for developing targeted immunotherapies and enhancing our knowledge of immune system dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCR V γ 3 Antibody (536) References:
- The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire. | Hernández, J., et al. 2000. J Immunol. 164: 596-602. PMID: 10623800
- Signal transduction by the TCR for antigen. | Kane, LP., et al. 2000. Curr Opin Immunol. 12: 242-9. PMID: 10781399
- A unique T cell receptor discovered in marsupials. | Parra, ZE., et al. 2007. Proc Natl Acad Sci U S A. 104: 9776-81. PMID: 17535902
- Circulating CD3+/T cell receptor V gamma 3+ fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells. | Payer, E., et al. 1991. J Immunol. 146: 2536-43. PMID: 1826696
- Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody. | Havran, WL., et al. 1989. Proc Natl Acad Sci U S A. 86: 4185-9. PMID: 2726770
- TCR V gene usage in autoimmunity. | Gold, DP. 1994. Curr Opin Immunol. 6: 907-12. PMID: 7536011
- Stimulation of TCR V gamma 3 cells by gram-negative bacteria. | Leclercq, G. and Plum, J. 1995. J Immunol. 154: 5313-9. PMID: 7730634
- TCR usage in human and experimental demyelinating disease. | Hafler, DA., et al. 1996. Immunol Today. 17: 152-9. PMID: 8871344
- CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. | Poccia, F., et al. 1997. J Immunol. 159: 6009-17. PMID: 9550399
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR V γ 3 Antibody (536) | sc-53027 | 200 µg/ml | $322.00 | |||
TCR V γ 3 Antibody (536) AC | sc-53027 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TCR V γ 3 Antibody (536) HRP | sc-53027 HRP | 200 µg/ml | $322.00 | |||
TCR V γ 3 Antibody (536) FITC | sc-53027 FITC | 200 µg/ml | $336.00 | |||
TCR V γ 3 Antibody (536) PE | sc-53027 PE | 200 µg/ml | $349.00 | |||
TCR V γ 3 Antibody (536) Alexa Fluor® 488 | sc-53027 AF488 | 200 µg/ml | $364.00 | |||
TCR V γ 3 Antibody (536) Alexa Fluor® 546 | sc-53027 AF546 | 200 µg/ml | $364.00 | |||
TCR V γ 3 Antibody (536) Alexa Fluor® 594 | sc-53027 AF594 | 200 µg/ml | $364.00 | |||
TCR V γ 3 Antibody (536) Alexa Fluor® 647 | sc-53027 AF647 | 200 µg/ml | $364.00 | |||
TCR V γ 3 Antibody (536) Alexa Fluor® 680 | sc-53027 AF680 | 200 µg/ml | $364.00 | |||
TCR V γ 3 Antibody (536) Alexa Fluor® 790 | sc-53027 AF790 | 200 µg/ml | $364.00 |