ZAG Antibody (F-4): sc-271278

ZAG Antibody (F-4) is a mouse monoclonal IgG2b antibody that detects ZAG (Zn-α2-glycoprotein) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZAG is a soluble, secreted protein predominantly found in serum and various body fluids, including cerebrospinal fluid, blood plasma, urine, and sweat. ZAG (F-4) antibody helps researchers study ZAG′s crucial role in lipid metabolism, as ZAG stimulates lipid degradation in adipocytes, which is particularly significant in obesity and metabolic disorders. ZAG overexpression has been linked to extensive fat losses observed in certain advanced cancers, highlighting ZAG′s potential as a biomarker for cancer cachexia. ZAG shares a high degree of sequence similarity with class-I major histocompatibility complex (MHC) antigens and features a large groove analogous to the peptide binding grooves of class I MHC, although ZAG does not bind the class I light chain β-2-Microglobulin. This unique structural characteristic may influence ZAG′s interactions and functions within the immune system and metabolic pathways. Anti-ZAG antibody (F-4) serves as an essential tool for researchers investigating ZAG′s roles in health and disease, providing valuable insights into its function and potential therapeutic applications.

The preferred ZAG antibody is ZAG Antibody (1D4): sc-13585.