ZAG Activators
The chemical class known as ZAG activators includes compounds that indirectly promote the expression or activity of the zinc-alpha2-glycoprotein (ZAG), which is involved in lipid metabolism and energy balance. These activators function through a variety of cellular pathways, often tied to metabolic regulation and energy expenditure. They encompass thyroid hormones such as liothyronine and thyroxine, which raise the metabolic rate, upregulating ZAG as a compensatory response. PPAR agonists like rosiglitazone and fenofibrate enhance adipocyte differentiation and fatty acid metabolism, respectively, processes in which ZAG expression is naturally upregulated.
Further members of this class are agents that increase intracellular cAMP levels, such as forskolin, that can initiate signaling cascades resulting in enhanced metabolic gene expression, including that of ZAG. Compounds like caffeine and isoproterenol stimulate the central nervous and sympathetic nervous systems, thereby increasing the demand for lipid mobilization and concomitantly ZAG activity. Niacin, despite its complex role in lipid regulation, along with capsaicin, which activates TRPV1 receptors, and selective beta3-adrenergic receptor agonists like CL 316,243, could increase metabolic rate and lipid mobilization, thereby influencing ZAG expression and activity. These diverse compounds do not directly interact with ZAG but activate its activity through the regulation of metabolic demand and lipid homeostasis in the body.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
L-3,3′,5-Triiodothyronine can enhance protein synthesis and energy consumption, potentially upregulating ZAG, which is implicated in lipid mobilization and metabolism. Increased metabolic demand can stimulate ZAG expression as part of the adaptive response to elevated energy requirements. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a PPAR-gamma agonist that can influence adipocyte differentiation and insulin sensitivity. By promoting adipocyte maturation, it can indirectly enhance ZAG expression, which is prominent in adipose tissue and involved in lipid mobilization, suggesting an adaptive role in lipid homeostasis influenced by PPAR-gamma activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression through retinoic acid receptors and can affect adipocyte differentiation. Its role in gene expression modulation may lead to the upregulation of ZAG, a protein that influences lipid metabolism, as part of the complex network of genes controlling adipogenesis. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate modulates lipid metabolism and can upregulate proteins involved in fatty acid transport and oxidation. These actions can elevate ZAG levels as part of the coordinated regulation of lipid mobilizing and catabolizing enzymes in response to increased fatty acid metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and stimulating PKA activity, which can lead to transcriptional changes of various metabolic genes. This cascade can promote ZAG expression indirectly by creating a favorable intracellular environment for the upregulation of metabolic processes, including those where ZAG is a key player. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can increase metabolic rate by stimulating the central nervous system and enhancing lipolysis. This stimulatory effect on metabolism may lead to increased expression of ZAG, which has a function in lipid mobilization, as a response to elevated energy expenditure. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin, while primarily known for glucose homeostasis, also affects lipid metabolism. By influencing the anabolic pathways, insulin can modulate ZAG expression indirectly, as ZAG is involved in the lipolytic pathway, potentially as a compensatory mechanism to regulate lipid levels in the presence of insulin. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase lipolysis and metabolic rate. The stimulation of beta-adrenergic receptors can enhance the expression of ZAG as it may be part of the adaptive mechanism to the increased demand for energy and mobilization of fat reserves. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin can have complex effects on lipid metabolism, and while it’s primarily known for its role in lowering lipids, it can also influence the expression of genes involved in energy metabolism. Increased expression of ZAG may occur as part of the broad changes in lipid metabolism induced by niacin. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the active component in chili peppers, can enhance metabolic rate via its action on the transient receptor potential vanilloid 1 (TRPV1). Activation of TRPV1 can lead to an increase in cellular calcium influx, influencing metabolic pathways, and possibly upregulating ZAG expression due to the increased metabolic demands. | ||||||