XIAP Antibody (D-2): sc-55552

XIAP Antibody (D-2) is a mouse monoclonal IgG2b antibody that detects XIAP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XIAP, or X-linked inhibitor of apoptosis protein, plays a crucial role in regulating apoptosis by inhibiting activated caspase-3, which is a key enzyme in the apoptotic pathway. This function is particularly important as XIAP helps prevent unwanted cell death, contributing to cell survival during stress conditions and in various diseases, including cancer. The structure of XIAP includes a baculovirus IAP repeat (BIR) motif that is essential for interaction with caspases, as well as a carboxy-terminal RING finger domain involved in ubiquitin ligase activity. This structural configuration allows XIAP to effectively inhibit apoptosis and positions XIAP as a significant player in cellular signaling pathways that regulate cell proliferation and survival. The ability of XIAP to modulate these pathways makes XIAP a valuable target for therapeutic interventions aimed at enhancing apoptosis in cancer cells or preventing excessive cell death in neurodegenerative diseases. Anti-XIAP antibody (D-2) is therefore an essential tool for researchers investigating the mechanisms of apoptosis and the potential for targeted therapies in various diseases.

The preferred XIAP antibody is XIAP Antibody (E-2): sc-55551.