WDR78 Antibody (E-2): sc-390401

WDR78 Antibody (E-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects WDR78 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-WDR78 antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WDR78, also known as WD repeat domain 78, is an 848 amino acid protein characterized by the presence of six WD repeats, which are structural motifs that typically form a propeller-like tertiary structure. This unique structure facilitates WDR78′s involvement in various cellular processes, including chromatin assembly, cell cycle regulation, signal transduction, RNA processing, apoptosis, and vesicular trafficking. WDR78 is encoded on human chromosome 1, which encompasses a large portion of the human genome and contains over 3,000 genes, highlighting WDR78′s significance in genetic regulation and cellular function.

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WDR78 Antibody (E-2) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family.  |  Koshizuka, Y., et al. 2001. Genomics. 72: 252-9. PMID: 11401440
3. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.  |  Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
4. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
5. Phylogenetic, structural and functional relationships between WD- and Kelch-repeat proteins.  |  Hudson, AM. and Cooley, L. 2008. Subcell Biochem. 48: 6-19. PMID: 18925367
6. Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.  |  Hu, S., et al. 2021. Gut. 70: 285-296. PMID: 32651235
7. Tumorigenic effects of TLX overexpression in HEK 293T cells.  |  Parris, TZ., et al. 2019. Cancer Rep (Hoboken). 2: e1204. PMID: 32721119
8. Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly.  |  Lu, S., et al. 2021. Cell Discov. 7: 110. PMID: 34782613
9. Tanreqing suppresses the proliferation and migration of non-small cell lung cancer cells by mediating the inactivation of the HIF1α signaling pathway via exosomal circ-WDR78.  |  Hong, W., et al. 2025. J Biomol Struct Dyn. 43: 2491-2502. PMID: 38247231
10. Development and Validation of a Prognostic Model based on 11 E3-related Genes for Colon Cancer Patients.  |  JIang, W., et al. 2024. Curr Pharm Des. 30: 935-951. PMID: 38898815
11. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
12. Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.  |  Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDR78 Antibody (E-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-WDR78 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDR78 Antibody (E-2) Specifications

Alternate Product Name: WDR78

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 455-487

Epitope Target: WDR78

Epitope Species: human

Product Reactivity/Detection: WDR78 isoforms

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for WDR78 Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin