VAP-1 Antibody (6D828): sc-73250

VAP-1 Antibody (6D828) is a mouse monoclonal IgG2a antibody that detects VAP-1 in human samples through applications such as western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). VAP-1, or vascular adhesion protein-1, plays a crucial role in the immune response by facilitating lymphocyte adhesion to the vascular endothelium, which is essential for immune cell migration from bloodstream to lymphoid tissues and inflammation sites. VAP-1 is primarily located on endothelial cell surfaces, where expression significantly increases under inflammatory conditions. VAP-1 functions as both an enzyme, specifically a monoamine oxidase, and an adhesion molecule, mediating lymphocyte adhesion and promoting recirculation. VAP-1 exists predominantly as a homodimer in vivo, and proper glycosylation is vital for immune cell trafficking function. VAP-1 is also expressed in various smooth muscle cells, although not supporting lymphocyte binding in these cells, instead playing a role in primary amine deamination, highlighting multifaceted functions in immune regulation and vascular biology. Elevated soluble VAP-1 levels in circulation have been associated with inflammatory liver diseases, making VAP-1 a potential biomarker for such conditions.

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VAP-1 Antibody (6D828) References:

1. Vascular adhesion protein-1 (VAP-1) mediates lymphocyte-endothelial interactions in chronic kidney rejection.  |  Kurkijärvi, R., et al. 2001. Eur J Immunol. 31: 2876-84. PMID: 11592062
2. Vascular adhesion protein-1 (VAP-1) is overexpressed in psoriatic patients.  |  Madej, A., et al. 2007. J Eur Acad Dermatol Venereol. 21: 72-8. PMID: 17207171
3. Localization of vascular adhesion protein-1 (VAP-1) in the human eye.  |  Almulki, L., et al. 2010. Exp Eye Res. 90: 26-32. PMID: 19761765
4. Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread.  |  Salmi, M. and Jalkanen, S. 2011. FEBS Lett. 585: 1543-50. PMID: 21515268
5. The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.  |  Noonan, T., et al. 2013. Am J Clin Exp Immunol. 2: 172-85. PMID: 23885334
6. Evaluation of serum and tissue levels of VAP-1 in colorectal cancer.  |  Ward, ST., et al. 2016. BMC Cancer. 16: 154. PMID: 26912327
7. Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection.  |  Kraemer, M., et al. 2019. J Clin Med. 8: PMID: 30658395
8. Assessment of relationship between serum vascular adhesion protein-1 (VAP-1) and gestational diabetes mellitus.  |  Dincgez Cakmak, B., et al. 2019. Biomarkers. 24: 750-756. PMID: 31638437
9. Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.  |  Jargaud, V., et al. 2021. J Physiol Biochem. 77: 141-154. PMID: 32712883
10. Vascular adhesion protein-1 (VAP-1)--a new adhesion molecule recruiting lymphocytes to sites of inflammation.  |  Jalkanen, S. and Salmi, M. 1993. Res Immunol. 144: 746-9; discussion 754-62. PMID: 8159873

The preferred VAP-1 antibody is VAP-1 Antibody (A-8): sc-166713.