UCP1 Antibody (E-6): sc-518171

UCP1 Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects UCP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-UCP1 antibody (E-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UCP1 is an integral membrane protein predominantly found in the mitochondria of brown adipose tissue, where UCP1 plays a crucial role in thermogenesis. UCP1 functions by forming a dimer that acts as a proton channel, allowing protons to re-enter the mitochondrial matrix without generating ATP, thereby dissipating the electrochemical gradient and producing heat instead. This process is vital for maintaining body temperature in cold environments and is also implicated in the regulation of glucose metabolism, making UCP1 a key player in energy expenditure and metabolic health. Additionally, UCP2, a structurally related protein, is expressed in a wider range of tissues, including white adipose tissue and muscle, and contributes to body weight regulation, highlighting the importance of these uncoupling proteins in overall metabolic processes.

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UCP1 Antibody (E-6) References:

1. Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway.  |  Xiong, W., et al. 2021. Theranostics. 11: 4637-4654. PMID: 33754018
2. Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes.  |  Lee, HS., et al. 2023. Arch Pharm Res. 46: 192-205. PMID: 36840853
3. Novel UCP1 knockout models broaden our understanding of mammalian non-shivering thermogenesis.  |  Jastroch, M. 2023. Acta Physiol (Oxf). 238: e13956. PMID: 36867076
4. UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.  |  Xiong, W., et al. 2023. J Transl Med. 21: 521. PMID: 37533052
5. HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1.  |  Tian, D., et al. 2023. Cell Signal. 111: 110875. PMID: 37640195
6. A newly identified compound activating UCP1 inhibits obesity and its related metabolic disorders.  |  Onodera, K., et al. 2024. Obesity (Silver Spring). 32: 324-338. PMID: 37974549
7. Liraglutide promotes UCP1 expression and lipolysis of adipocytes by promoting the secretion of irisin from skeletal muscle cells.  |  Zhang, N., et al. 2024. Mol Cell Endocrinol. 588: 112225. PMID: 38570133
8. UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.  |  Kwok, TC., et al. 2024. Eur J Endocrinol. 191: 106-115. PMID: 38917410
9. Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis.  |  Gu, M., et al. 2024. Cell Death Dis. 15: 518. PMID: 39033153
10. Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.  |  Vargas-Castillo, A., et al. 2024. Cell Metab. 36: 2146-2155.e5. PMID: 39084217

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UCP1 Antibody (E-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-UCP1 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UCP1 Antibody (E-6) Specifications

Alternate Product Name: UCP1

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 195-214

Epitope Target: UCP1

Epitope Species: human

Product Reactivity/Detection: UCP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for UCP1 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred UCP1 antibody is UCP1 Antibody (4E5): sc-293418.