Date published: 2025-10-10

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UCP1 Antibodies

Santa Cruz Biotechnology offers a broad range of UCP1 monoclonal antibodies for research focused on understanding uncoupling protein 1 (UCP1) in thermogenesis and energy metabolism. UCP1 monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). UCP1 is a specialized protein found in brown adipose tissue, where it plays a vital role in non-shivering thermogenesis by dissipating the proton gradient generated by the electron transport chain. This process is essential for maintaining body temperature in cold environments and contributes to energy expenditure and metabolic regulation. Understanding UCP1 function has become increasingly important in research related to obesity and metabolic disorders. Studying UCP1 expression and activity provides researchers with crucial information about brown adipose tissue function and its role in energy homeostasis. Investigating UCP1 regulation and activation mechanisms helps advance our knowledge of thermogenic processes and metabolic health. Research utilizing UCP1 monoclonal antibodies contributes significantly to expanding scientific understanding of metabolic diseases and potential therapeutic approaches. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific knowledge in metabolic research and therapeutic development.

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UCP1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

UCP1 Antibody (A-6)

sc-518024mouse IgG2a κ284-307 (m)WB, IP, IF, IHC(P), ELISAm, r
7
(1)

UCP1 Antibody (4E5)

sc-293418mouse IgG2a κ232-267 (h)WB, IP, ELISAm, r, h
24
(17)

UCP1 Antibody (E-6)

sc-518171mouse IgG1 κ195-214 (h)WB, IP, IF, ELISAm, r, h
1
(1)

UCP1 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

UCP1 CRISPR/Cas9 KO Plasmid (h)

sc-400410hGene KnockoutGFP0
(0)

UCP1 HDR Plasmid (h)

sc-400410-HDRhHomology Directed RepairPuromycin0
(0)

UCP1 Double Nickase Plasmid (h)

sc-400410-NIChGene KnockoutPuromycin0
(0)

UCP1 Double Nickase Plasmid (h2)

sc-400410-NIC-2hGene KnockoutPuromycin0
(0)

UCP1 CRISPR/Cas9 KO Plasmid (m)

sc-423595-KO-2mGene KnockoutGFP0
(0)

UCP1 HDR Plasmid (m2)

sc-423595-HDR-2mHomology Directed RepairPuromycin0
(0)

UCP1 Double Nickase Plasmid (m)

sc-423595-NICmGene KnockoutPuromycin0
(0)

UCP1 Double Nickase Plasmid (m2)

sc-423595-NIC-2mGene KnockoutPuromycin0
(0)

UCP1 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

UCP1 CRISPR Activation Plasmid (h)

sc-400410-ACThGene ActivationPuro, Blast, Hygro0
(0)

UCP1 CRISPR Activation Plasmid (h2)

sc-400410-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

UCP1 Lentiviral Activation Particles (h)

sc-400410-LAChGene ActivationPuro, Blast, Hygro0
(0)

UCP1 Lentiviral Activation Particles (h2)

sc-400410-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

UCP1 CRISPR Activation Plasmid (m)

sc-423595-ACTmGene ActivationPuro, Blast, Hygro0
(0)

UCP1 CRISPR Activation Plasmid (m2)

sc-423595-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

UCP1 Lentiviral Activation Particles (m)

sc-423595-LACmGene ActivationPuro, Blast, Hygro0
(0)

UCP1 Lentiviral Activation Particles (m2)

sc-423595-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

UCP1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

UCP1 siRNA (h)

sc-42680hGene SilencingN/A0
(0)

UCP1 shRNA Plasmid (h)

sc-42680-SHhGene SilencingPuromycin0
(0)

UCP1 shRNA (h) Lentiviral Particles

sc-42680-VhGene SilencingPuromycin0
(0)

UCP1 siRNA (m)

sc-42681mGene SilencingN/A
1
(0)

UCP1 shRNA Plasmid (m)

sc-42681-SHmGene SilencingPuromycin
1
(0)

UCP1 shRNA (m) Lentiviral Particles

sc-42681-VmGene SilencingPuromycin
1
(0)