UCP1 Activators
Common UCP1 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Rosiglitazone CAS 122320-73-4, L-3,3′,5-Triiodothyronine, free acid CAS 6893-02-3, Capsaicin CAS 404-86-4 and Anandamide CAS 94421-68-8.
UCP1 (Uncoupling Protein 1) Activators belong to a distinctive chemical class that has captured scientific interest due to their ability to activate UCP1 function, a mitochondrial protein found in brown adipose tissue (BAT). These activators function by influencing the interactions and pathways involving UCP1, which plays a crucial role in thermogenesis and energy expenditure. UCP1 is known for its ability to uncouple oxidative phosphorylation from ATP synthesis, leading to the dissipation of proton gradients as heat. This process is critical for heat generation and energy regulation in BAT, particularly in small mammals and human infants. UCP1 Activators are thoughtfully designed to target specific mechanisms or pathways associated with UCP1, thus influencing its cellular functions and downstream effects on energy metabolism and heat production.
The development of UCP1 Activators requires a comprehensive understanding of the structural attributes of UCP1 and its interactions with mitochondrial membranes, fatty acids, and other regulatory factors. Researchers in this field work to engineer molecules that promote the activation of UCP1, contributing to its role in mediating energy dissipation and thermogenesis. These activators often employ innovative design strategies that enhance UCP1's functional role in promoting proton leak and heat production. By gaining insights into the intricate mechanisms through which UCP1 participates in energy metabolism and thermoregulation, researchers aim to unravel its significance in fundamental physiological processes. Ongoing advancements in molecular pharmacology and chemical synthesis drive the refinement of UCP1 Activators, offering applications across diverse scientific domains where manipulation of UCP1-mediated processes is of interest.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist that activates cAMP signaling, leading to UCP1 expression and thermogenesis in brown adipose tissue. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, can induce UCP1 expression and contribute to brown adipocyte differentiation and thermogenesis. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPARγ agonist that stimulates UCP1 expression and promotes brown adipocyte activity and energy expenditure. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
Thyroid hormone triiodothyronine (T3) is a key regulator of UCP1 expression, promoting thermogenesis in brown adipose tissue. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, an ingredient in chili peppers, activates TRPV1 receptors and triggers UCP1 expression in brown adipose tissue. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estrogen can modulate UCP1 expression and energy metabolism in adipose tissue, contributing to sexual dimorphism in adipocyte function. | ||||||