TORC2 Antibody (G-4): sc-166445
- TORC2 Antibody (G-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 406-615 mapping near the C-terminus of TORC2 of human origin
- TORC2 Antibody (G-4) is recommended for detection of TORC2 of human origin by WB, IP, IF and ELISA
- Anti-TORC2 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-166445 X, 200 µg/0.1 ml)
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TORC2 (G-4): sc-166445.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TORC2 Antibody (G-4) for WB applications. These reagents are now offered in bundles with TORC2 Antibody (G-4) (see ordering information below).
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TORC2 Antibody (G-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects TORC2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TORC2 (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The TORC (transducer of regulated cAMP response element-binding) proteins, which include TORC1 and TORC2, play a crucial role as coactivators of the cAMP response element-binding protein (CREB), facilitating the transcription of genes in response to hormonal signals. TORC2 is primarily located in the nucleus, where TORC2 is involved in the regulation of gene expression by modulating CREB activity. Nuclear localization is essential for TORC2 function, as direct influence on transcriptional machinery and response to cellular signals impacts processes such as metabolism, cell growth, and differentiation. TORC protein translocation from the nucleus is a critical step in activating CRE-mediated gene expression, highlighting spatial regulation importance in cellular signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TORC2 Antibody (G-4) References:
- The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. | Screaton, RA., et al. 2004. Cell. 119: 61-74. PMID: 15454081
- Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. | Canettieri, G., et al. 2005. Cell Metab. 2: 331-8. PMID: 16271533
- Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. | Yang, Q., et al. 2006. Genes Dev. 20: 2820-32. PMID: 17043309
- Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. | Dentin, R., et al. 2007. Nature. 449: 366-9. PMID: 17805301
- Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1. | Jiang, S., et al. 2009. Retrovirology. 6: 73. PMID: 19664292
- The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells. | Gravina, GL., et al. 2011. Endocr Relat Cancer. 18: 385-400. PMID: 21551258
- CREB coactivator CRTC2/TORC2 and its regulator calcineurin crucially mediate follicle-stimulating hormone and transforming growth factor β1 upregulation of steroidogenesis. | Fang, WL., et al. 2012. J Cell Physiol. 227: 2430-40. PMID: 21826657
- TORC2 inhibition may boost DNA-damaging chemotherapy. | Stucki, M. 2015. Oncotarget. 6: 586-7. PMID: 25575819
- TORC2/3-mediated DUSP1 upregulation is essential for human decidualization. | Xu, C., et al. 2021. Reproduction. 161: 573-580. PMID: 33780908
- TORC2 is required for the accumulation of γH2A in response to DNA damage. | Cohen, A., et al. 2024. J Biol Chem. 300: 107531. PMID: 38971312
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TORC2 Antibody (G-4) | sc-166445 | 200 µg/ml | $316.00 | |||
TORC2 Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-528970 | 200 µg Ab; 10 µg BP | $354.00 | |||
TORC2 Antibody (G-4): m-IgGκ BP-HRP Bundle | sc-521612 | 200 µg Ab, 40 µg BP | $354.00 | |||
TORC2 Antibody (G-4): m-IgG1 BP-HRP Bundle | sc-543246 | 200 µg Ab; 20 µg BP | $354.00 | |||
TORC2 Antibody (G-4) X | sc-166445 X | 200 µg/0.1 ml | $316.00 | |||
TORC2 Antibody (G-4) AC | sc-166445 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TORC2 Antibody (G-4) HRP | sc-166445 HRP | 200 µg/ml | $316.00 | |||
TORC2 Antibody (G-4) FITC | sc-166445 FITC | 200 µg/ml | $330.00 | |||
TORC2 Antibody (G-4) PE | sc-166445 PE | 200 µg/ml | $343.00 | |||
TORC2 Antibody (G-4) Alexa Fluor® 488 | sc-166445 AF488 | 200 µg/ml | $357.00 | |||
TORC2 Antibody (G-4) Alexa Fluor® 546 | sc-166445 AF546 | 200 µg/ml | $357.00 | |||
TORC2 Antibody (G-4) Alexa Fluor® 594 | sc-166445 AF594 | 200 µg/ml | $357.00 | |||
TORC2 Antibody (G-4) Alexa Fluor® 647 | sc-166445 AF647 | 200 µg/ml | $357.00 | |||
TORC2 Antibody (G-4) Alexa Fluor® 680 | sc-166445 AF680 | 200 µg/ml | $357.00 | |||
TORC2 Antibody (G-4) Alexa Fluor® 790 | sc-166445 AF790 | 200 µg/ml | $357.00 |