TORC2 Antibody (F-4): sc-271912

TORC2 Antibody (F-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects TORC2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TORC2 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The TORC (transducer of regulated cAMP response element-binding) proteins, which include TORC1 and TORC2, play a crucial role as coactivators of the cAMP response element-binding protein (CREB), facilitating gene transcription in response to cAMP signaling. TORC2 is primarily located in the nucleus, where TORC2 regulates gene expression by modulating CREB activity. This nuclear localization enables TORC2 to directly influence transcriptional machinery, impacting various cellular processes such as metabolism, cell growth, and differentiation. TORC protein translocation from the nucleus is a critical step in activating CRE-mediated gene expression, highlighting spatial regulation importance in cellular signaling pathways.

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TORC2 Antibody (F-4) References:

1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.  |  Iourgenko, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 12147-52. PMID: 14506290
2. TORCs: transducers of regulated CREB activity.  |  Conkright, MD., et al. 2003. Mol Cell. 12: 413-23. PMID: 14536081
3. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.  |  Screaton, RA., et al. 2004. Cell. 119: 61-74. PMID: 15454081
4. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.  |  Bittinger, MA., et al. 2004. Curr Biol. 14: 2156-61. PMID: 15589160
5. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.  |  Behboudi, A., et al. 2005. Genes Chromosomes Cancer. 43: 202-5. PMID: 15729701
6. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.  |  Koo, SH., et al. 2005. Nature. 437: 1109-11. PMID: 16148943
7. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.  |  Ravnskjaer, K., et al. 2007. EMBO J. 26: 2880-9. PMID: 17476304
8. TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation.  |  Kuraishy, AI., et al. 2007. Proc Natl Acad Sci U S A. 104: 10175-80. PMID: 17548807
9. Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.  |  Jansson, D., et al. 2008. Proc Natl Acad Sci U S A. 105: 10161-6. PMID: 18626018
10. Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.  |  Hoang, B., et al. 2010. Blood. 116: 4560-8. PMID: 20686120
11. Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.  |  Berchtold, D., et al. 2012. Nat Cell Biol. 14: 542-7. PMID: 22504275
12. The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro.  |  Becker, MN., et al. 2014. Urol Oncol. 32: 317-26. PMID: 24054871

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TORC2 Antibody (F-4) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-TORC2 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TORC2 Antibody (F-4) Specifications

Alternate Product Name: TORC2

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: TORC2

Epitope Species: human

Product Reactivity/Detection: TORC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for TORC2 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent