Thrombin R Antibody (G-7): sc-133128

Thrombin R Antibody (G-7) is a mouse monoclonal IgG2a antibody that detects Thrombin R in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Thrombin R, also known as protease-activated receptor-1 (PAR-1), plays a crucial role in mediating the effects of thrombin, a key serine protease involved in blood coagulation and platelet aggregation. Thrombin R (G-7) antibody helps researchers study PAR-1′s ability to activate intracellular signaling pathways upon thrombin binding, which leads to physiological responses such as platelet activation and vascular remodeling. PAR-1 is primarily located on the surface of platelets and endothelial cells, where PAR-1 undergoes a unique process of internalization and degradation following activation. This internalization is essential for regulating signaling capacity and preventing excessive activation, which could lead to pathological conditions such as thrombosis. Additionally, PAR-1 interacts with other members of the G protein-coupled receptor family, including PAR-2 and PAR-3, highlighting PAR-1′s role in a complex network of signaling pathways that govern hemostasis and inflammation. Anti-Thrombin R antibody (G-7) serves as an invaluable tool for researchers studying these critical processes in human health and disease.

The preferred Thrombin R antibody is Thrombin R Antibody (ATAP2): sc-13503.