Thrombin R Activators
Common Thrombin R Activators include, but are not limited to PMA CAS 16561-29-8, Dexamethasone CAS 50-02-2, Forskolin CAS 66575-29-9, Retinoic Acid, all trans CAS 302-79-4 and Hydrogen Peroxide CAS 7722-84-1.
Thrombin R, also known as the protease-activated receptor 1 (PAR1), is a member of the protease-activated receptor family. These receptors are a unique class of G protein-coupled receptors (GPCRs) activated by proteolytic cleavage. Specifically, PAR1 is activated by thrombin, a serine protease that plays a central role in the clotting cascade. Once activated, thrombin cleaves the extracellular domain of PAR1, exposing a tethered ligand that then binds to the receptor, initiating a cascade of intracellular events. The activation of PAR1 leads to various cellular responses including cell adhesion, cell migration, secretion, and proliferation, underscoring its importance in physiological processes such as hemostasis, inflammation, and tissue repair.
Thrombin R Activators are a collection of chemical compounds that are specifically designed to boost or augment the activity of the thrombin receptor, PAR1. By enhancing the receptor's activity, these activators can modulate the aforementioned cellular processes that PAR1 is involved in. The modulation of PAR1 activity through these activators can have profound effects on cellular signaling, influencing the intricate balance between coagulation and anticoagulation, and modulating inflammatory responses. Furthermore, due to PAR1's involvement in cell adhesion and migration, activators can also play a role in modulating cell mobility and interactions. The study and characterization of Thrombin R activators provide a deeper understanding of the molecular mechanisms that drive these cellular responses and offer insights into the intricate balance of cellular signaling in the context of hemostasis and inflammation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS is a bacterial endotoxin that induces inflammatory responses, which might stimulate the expression of PAR1 in vascular endothelial cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC and can modulate various cellular responses, potentially influencing PAR1 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This corticosteroid has anti-inflammatory effects and might modulate PAR1 expression in certain cellular contexts. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, potentially modulating PAR1 expression in certain cell types. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Given its role in coagulation, Heparin sodium salt might indirectly influence the expression of receptors like PAR1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression in various cell types and might influence PAR1 expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an inducer of oxidative stress, hydrogen peroxide might affect PAR1 expression in vascular endothelial cells. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Statins, like atorvastatin, can modulate various cellular pathways and might have an impact on PAR1 expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
By modulating cellular responses and signaling, rosiglitazone might indirectly influence PAR1 expression. | ||||||