Thrombin R Antibody (C-11): sc-271100
- Thrombin R Antibody (C-11) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 37-63 near the N-terminus of Thrombin R of human origin
- recommended for detection of Thrombin R of mouse, rat and human origin by WB, IP, IF and ELISA
- See Thrombin R (ATAP2): sc-13503 for Thrombin R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Thrombin R Antibody (C-11) for WB applications. These reagents are now offered in bundles with Thrombin R Antibody (C-11) (see ordering information below).
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Thrombin R Antibody (C-11) is a mouse monoclonal IgG2a antibody that detects Thrombin R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Thrombin R, also known as protease-activated receptor-1 (PAR-1), plays a crucial role in mediating the effects of thrombin, a key serine protease involved in blood coagulation and platelet aggregation. Thrombin R (C-11) antibody recognizes a protein primarily located on the surface of platelets and endothelial cells, where PAR-1 facilitates rapid response to thrombin during hemostasis. Upon activation, PAR-1 undergoes a conformational change that allows interaction with G proteins, triggering an increase in intracellular calcium levels and subsequent cellular responses. Additionally, PAR-1 is subject to post-translational modifications, such as phosphorylation, which can influence activity and regulatory mechanisms. Anti-Thrombin R antibody (C-11) serves as an essential tool for researchers studying thrombin signaling pathways and their implications in various cardiovascular diseases and disorders related to hemostasis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombin R Antibody (C-11) | sc-271100 | 200 µg/ml | $322.00 | |||
Thrombin R Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-540203 | 200 µg Ab; 10 µg BP | $361.00 | |||
Thrombin R Antibody (C-11): m-IgG2a BP-HRP Bundle | sc-546873 | 200 µg Ab; 10 µg BP | $361.00 | |||
Thrombin R (C-11) Neutralizing Peptide | sc-271100 P | 100 µg/0.5 ml | $69.00 |