SUV39H1 Antibody (C-10): sc-377112
- SUV39H1 Antibody (C-10) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 166-220 of SUV39H1 of human origin
- SUV39H1 Antibody (C-10) is recommended for detection of SUV39H1 of human origin by WB, IP, IF and ELISA
- Anti-SUV39H1 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SUV39H1 Antibody (C-10) for WB applications. These reagents are now offered in bundles with SUV39H1 Antibody (C-10) (see ordering information below).
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SUV39H1 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects SUV39H1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SUV39H1 antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SUV39H1 plays a crucial role in regulating chromatin structure and gene expression through its function as a histone methyltransferase, specifically methylating Lysine 9 of Histone H3. This modification creates a binding site for heterochromatin protein 1 (HP1), which is essential for gene silencing and maintaining heterochromatin integrity. SUV39H1 presence at heterochromatic regions during interphase and localization at centromeres during metaphase depend on its C-terminal SET domain, highlighting SUV39H1′s importance in chromosomal organization. Additionally, phosphorylation of SUV39H1 at the G1/S transition of the cell cycle can influence activity and cellular functions. When overexpressed, SUV39H1 suppresses cell growth, indicating a role as a long-range repressor capable of silencing basal promoters over several kilobases. This multifaceted involvement in chromatin dynamics and gene regulation underscores SUV39H1′s significance in cellular processes and potential as a target for research in epigenetics and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SUV39H1 Antibody (C-10) References:
- SUV39H1 regulates corneal epithelial wound healing via H3K9me3-mediated repression of p27. | Yang, S., et al. 2022. Eye Vis (Lond). 9: 4. PMID: 35101125
- CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas. | Niborski, LL., et al. 2022. Nat Commun. 13: 3739. PMID: 35768432
- Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP. | Li, R., et al. 2023. Mech Ageing Dev. 215: 111868. PMID: 37666472
- SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice. | Niu, W., et al. 2023. Cell Transplant. 32: 9636897231198167. PMID: 37811706
- SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma. | Zhang, Y., et al. 2023. BMC Cancer. 23: 1159. PMID: 38017386
- Deleting SUV39H1 in CAR-T cells epigenetically enhances the antitumor function. | Wang, Y., et al. 2024. MedComm (2020). 5: e552. PMID: 38645666
- SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma. | Li, C., et al. 2024. bioRxiv.. PMID: 39229036
- SUV39H1 epigenetically modulates the MCPIP1-AURKA signaling axis to enhance neuroblastoma tumorigenesis. | Li, M., et al. 2024. Oncogene. 43: 3306-3320. PMID: 39300256
- Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation. | Kim, HS., et al. 2024. Nat Commun. 15: 9384. PMID: 39477922
- Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury. | Li, Z., et al. 2024. Redox Biol. 78: 103414. PMID: 39603205
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SUV39H1 Antibody (C-10) | sc-377112 | 200 µg/ml | $316.00 | |||
SUV39H1 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-529976 | 200 µg Ab; 10 µg BP | $354.00 | |||
SUV39H1 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-523192 | 200 µg Ab, 40 µg BP | $354.00 | |||
SUV39H1 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-543798 | 200 µg Ab; 20 µg BP | $354.00 | |||
SUV39H1 Antibody (C-10) AC | sc-377112 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SUV39H1 Antibody (C-10) HRP | sc-377112 HRP | 200 µg/ml | $316.00 | |||
SUV39H1 Antibody (C-10) FITC | sc-377112 FITC | 200 µg/ml | $330.00 | |||
SUV39H1 Antibody (C-10) PE | sc-377112 PE | 200 µg/ml | $343.00 | |||
SUV39H1 Antibody (C-10) Alexa Fluor® 488 | sc-377112 AF488 | 200 µg/ml | $357.00 | |||
SUV39H1 Antibody (C-10) Alexa Fluor® 546 | sc-377112 AF546 | 200 µg/ml | $357.00 | |||
SUV39H1 Antibody (C-10) Alexa Fluor® 594 | sc-377112 AF594 | 200 µg/ml | $357.00 | |||
SUV39H1 Antibody (C-10) Alexa Fluor® 647 | sc-377112 AF647 | 200 µg/ml | $357.00 | |||
SUV39H1 Antibody (C-10) Alexa Fluor® 680 | sc-377112 AF680 | 200 µg/ml | $357.00 | |||
SUV39H1 Antibody (C-10) Alexa Fluor® 790 | sc-377112 AF790 | 200 µg/ml | $357.00 |