spectrin β I Antibody (VD4): sc-53901

spectrin β I Antibody (VD4) is a mouse monoclonal IgG2b antibody that detects spectrin β I in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Spectrin β I plays a crucial role in maintaining the structural integrity and stability of the cytoskeleton, particularly in erythrocytes, where spectrin β I forms part of the spectrin-actin network that underpins the plasma membrane. This network is vital for preserving the biconcave shape of red blood cells, which is essential for their flexibility and ability to navigate through the microvasculature. Proper functioning of spectrin β I is not only important for erythrocyte morphology but also for cellular signaling and the organization of membrane proteins, which can influence various physiological processes. Additionally, spectrin β I interacts with other cytoskeletal proteins, such as actin and protein 4.1, to form a complex that is essential for the mechanical properties of the cell membrane. Disruptions in the spectrin network can lead to various hematological disorders, highlighting the importance of spectrin β I in both health and disease. Anti-spectrin β I antibody (VD4) is an invaluable tool for researchers studying the dynamics of the cytoskeleton and its implications in cellular function and pathology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

spectrin β I Antibody (VD4) References:

1. Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection.  |  Swaminathan, S., et al. 2013. Cytokine Growth Factor Rev. 24: 571-7. PMID: 23962745
2. Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy.  |  Gu, FF., et al. 2016. J Hematol Oncol. 9: 66. PMID: 27496196
3. Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.  |  Calabrese, GM., et al. 2017. Cell Syst. 4: 46-59.e4. PMID: 27866947
4. Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity.  |  Zhu, ZL., et al. 2018. Mol Med Rep. 17: 109-116. PMID: 29115457
5. Bioinformatics and integrated analyses of prognosis-associated key genes in lung adenocarcinoma.  |  Zhu, H., et al. 2021. J Thorac Dis. 13: 1172-1186. PMID: 33717590
6. β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia.  |  Ma, X., et al. 2021. J Cell Mol Med. 25: 11300-11309. PMID: 34799994
7. iASPP regulates neurite development by interacting with Spectrin proteins.  |  Wang, J., et al. 2023. Front Mol Neurosci. 16: 1154770. PMID: 37284462
8. Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, autophagy, and YB-1 independent manner.  |  Imamichi, T., et al. 2023. PLoS One. 18: e0287829. PMID: 37910521
9. Diverse clinical presentation of SPTBN1 variants: Complex versus primary attention-deficit/hyperactivity disorder.  |  O'Connell, M., et al. 2025. Am J Med Genet A. 197: e63851. PMID: 39162370
10. Proteomic profiling of cerebrospinal fluid reveals TKT as a potential biomarker for medulloblastoma.  |  Kim, JW., et al. 2024. Sci Rep. 14: 21053. PMID: 39251709

The preferred spectrin β I antibody is spectrin β I Antibody (B-1): sc-374309.