SNFT Antibody (D-6): sc-398902
- SNFT Antibody (D-6) is a mouse monoclonal IgG2b κ SNFT antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-19 at the N-terminus of SNFT of human origin
- SNFT Antibody (D-6) is recommended for detection of SNFT of human origin by WB, IP, IF and ELISA
- Anti-SNFT Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-398902 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SNFT Antibody (D-6) for WB applications. These reagents are now offered in bundles with SNFT Antibody (D-6) (see ordering information below).
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SEE ALSO...
SNFT Antibody (D-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects SNFT of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SNFT antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNFT, also known as BATF3 (basic leucine zipper transcription factor, ATF-like 3), JUNDM1, or JDP1, is a 127 amino acid protein that plays a crucial role in regulating gene expression by localizing to the nucleus and containing a bZIP domain. This domain is essential for SNFT function as it allows interaction with c-Jun, acting as a negative regulator of AP-1-mediated transcription. By heterodimerizing with c-Jun and binding to specific DNA response elements, SNFT modulates the transcriptional activity of genes involved in various cellular processes, including cell proliferation and differentiation. The gene encoding SNFT is located on human chromosome 1, a region spanning 260 million base pairs and containing over 3,000 genes, with associations to numerous diseases, including familial adenomatous polyposis, Stickler syndrome, and various cancers. Understanding SNFT function and regulatory mechanisms is vital for elucidating its role in health and disease, particularly in cancer biology and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SNFT Antibody (D-6) References:
- Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. | Iacobelli, M., et al. 2000. J Immunol. 165: 860-8. PMID: 10878360
- Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. | Bower, KE., et al. 2002. J Biol Chem. 277: 34967-77. PMID: 12087103
- Comprehensive identification of human bZIP interactions with coiled-coil arrays. | Newman, JR. and Keating, AE. 2003. Science. 300: 2097-101. PMID: 12805554
- Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. | Bower, KE., et al. 2004. Oncogene. 23: 8805-14. PMID: 15467742
- Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. | Hildner, K., et al. 2008. Science. 322: 1097-100. PMID: 19008445
- The AP-1 transcription factor Batf controls T(H)17 differentiation. | Schraml, BU., et al. 2009. Nature. 460: 405-9. PMID: 19578362
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNFT Antibody (D-6) | sc-398902 | 200 µg/ml | $316.00 | |||
SNFT Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-530960 | 200 µg Ab; 10 µg BP | $354.00 | |||
SNFT Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-524527 | 200 µg Ab, 40 µg BP | $354.00 | |||
SNFT Antibody (D-6): m-IgG2b BP-HRP Bundle | sc-550242 | 200 µg Ab; 10 µg BP | $354.00 | |||
SNFT Antibody (D-6) X | sc-398902 X | 200 µg/0.1 ml | $316.00 | |||
SNFT Antibody (D-6) AC | sc-398902 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SNFT Antibody (D-6) HRP | sc-398902 HRP | 200 µg/ml | $316.00 | |||
SNFT Antibody (D-6) FITC | sc-398902 FITC | 200 µg/ml | $330.00 | |||
SNFT Antibody (D-6) PE | sc-398902 PE | 200 µg/ml | $343.00 | |||
SNFT Antibody (D-6) Alexa Fluor® 488 | sc-398902 AF488 | 200 µg/ml | $357.00 | |||
SNFT Antibody (D-6) Alexa Fluor® 546 | sc-398902 AF546 | 200 µg/ml | $357.00 | |||
SNFT Antibody (D-6) Alexa Fluor® 594 | sc-398902 AF594 | 200 µg/ml | $357.00 | |||
SNFT Antibody (D-6) Alexa Fluor® 647 | sc-398902 AF647 | 200 µg/ml | $357.00 | |||
SNFT Antibody (D-6) Alexa Fluor® 680 | sc-398902 AF680 | 200 µg/ml | $357.00 | |||
SNFT Antibody (D-6) Alexa Fluor® 790 | sc-398902 AF790 | 200 µg/ml | $357.00 | |||
SNFT (D-6) Neutralizing Peptide | sc-398902 P | 100 µg/0.5 ml | $68.00 |