SMS2 Antibody (7D10): sc-293384

SMS2 Antibody (7D10) is a mouse monoclonal IgG2a kappa light chain antibody that detects SMS2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SMS2 antibody (7D10) is available as a non-conjugated format. The SMS (sphingomyelin synthase) family, which includes SMS1 and SMS2, plays a crucial role in lipid metabolism, particularly in sphingomyelin synthesis, a vital component of cell membranes. SMS2 is primarily located at the plasma membrane, where SMS2 functions as a bidirectional lipid cholinephosphotransferase, converting phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol, and vice versa, depending on substrate concentrations. This regulation is essential for maintaining cellular homeostasis and signaling, as sphingomyelin is involved in various cellular processes, including apoptosis and cell survival. SMS2 activity can be influenced by various factors, including specific inhibitors like Tricyclodecan-9-yl-xanthogenate (D609), which has been shown to inhibit SMS activity and contribute to tumor cell cytotoxicity. SMS2 expression is observed in several tissues such as liver, muscle, heart, brain, stomach, and kidney, highlighting SMS2′s importance in diverse physiological functions.

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SMS2 Antibody (7D10) References:

1. Identification of a family of animal sphingomyelin synthases.  |  Huitema, K., et al. 2004. EMBO J. 23: 33-44. PMID: 14685263
2. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells.  |  Meng, A., et al. 2004. Exp Cell Res. 292: 385-92. PMID: 14697345
3. Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.  |  Yamaoka, S., et al. 2004. J Biol Chem. 279: 18688-93. PMID: 14976195
4. The mouse sphingomyelin synthase 1 (SMS1) gene is alternatively spliced to yield multiple transcripts and proteins.  |  Yang, Z., et al. 2005. Gene. 363: 123-32. PMID: 16226406
5. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?  |  Luberto, C. and Hannun, YA. 1998. J Biol Chem. 273: 14550-9. PMID: 9603970

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMS2 Antibody (7D10) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SMS2 Antibody (7D10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMS2 Antibody (7D10) Specifications

Alternate Product Name: SMS2

Product Clone Name: 7D10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 2-80

Epitope Target: SMS2

Epitope Species: human

Product Reactivity/Detection: SMS2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SMS2 Antibody (7D10): N/A