SMS2 Activators
SMS2 activators encompass a range of chemical compounds that facilitate the catalytic activity of the enzyme. These compounds include Sphingosine, Fumonisin B1, Palmitoyl-CoA, Sphingosine 1-Phosphate (S1P), Anandamide, Arachidonic Acid, Stearoyl-CoA, Oleic Acid, Linoleic Acid, Myriocin, Palmitic Acid, and Sphinganine. The compounds can be classified into two categories based on their functional roles: direct substrates and indirect enhancers.Sphingosine is a direct substrate that SMS2 uses to convert into ceramide, a critical step in the sphingolipid metabolic pathway. The enzyme's functional activity is enhanced by the presence of Sphingosine, which it utilizes directly in its catalytic process.
The indirect enhancers function by increasing the availability of substrates for SMS2 or contributing to the pool of sphingolipids. Fumonisin B1, a mycotoxin, inhibits ceramide synthase, leading to an accumulation of sphinganine and sphingosine, the substrates for SMS2. Palmitoyl-CoA, Stearoyl-CoA, and Palmitic Acid act as substrates for ceramide synthesis, and their increased availability can contribute to an increase in ceramide levels, indirectly enhancing the activity of SMS2. S1P, a sphingolipid metabolite, provides sphingosine when broken down, indirectly enhancing SMS2 by providing additional substrate. Anandamide, an endocannabinoid, and Arachidonic Acid can be metabolized to ceramide, hence indirectly enhancing the activity of SMS2. Oleic Acid and Linoleic Acid, fatty acids, can be incorporated into sphingolipids, indirectly enhancing the activity of SMS2 by contributing to the pool of sphingolipids. Lastly, Myriocin, an inhibitor of serine palmitoyltransferase, reduces sphingolipid synthesis and increases the availability of sphingosine, indirectly enhancing the activity of SMS2.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine is a long-chain base backbone of sphingolipids, which is converted into ceramide by SMS2. The availability of sphingosine can directly enhance the functional activity of SMS2 by providing the necessary substrate. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $200.00 $680.00 | 18 | |
Fumonisin B1 is a mycotoxin that inhibits ceramide synthase, leading to accumulation of sphinganine and sphingosine, the substrates for SMS2. This can indirectly enhance the activity of SMS2 by increasing the availability of its substrates. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a sphingolipid metabolite that, when broken down, provides sphingosine, a direct substrate for SMS2. Increased levels of S1P can indirectly enhance the activity of SMS2 by providing additional substrate. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid can be metabolized to ceramide, which is a substrate for SMS2. Increased availability of Arachidonic Acid can indirectly enhance the functional activity of SMS2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Stearoyl-CoA acts as a substrate for ceramide synthesis. Increased availability of Stearoyl-CoA can contribute to increased ceramide levels, and thus, indirectly enhance the activity of SMS2. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid is a monounsaturated fatty acid which can be incorporated into sphingolipids. Increased availability of Oleic Acid can indirectly enhance the activity of SMS2 by contributing to the pool of sphingolipids. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid is a polyunsaturated fatty acid which can be incorporated into sphingolipids. Increased availability of Linoleic Acid can indirectly enhance the activity of SMS2 by contributing to the pool of sphingolipids. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $150.00 | 8 | |
Myriocin is a potent inhibitor of serine palmitoyltransferase, leading to reduced sphingolipid synthesis and increased availability of sphingosine, a substrate for SMS2. This could indirectly enhance the activity of SMS2. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic Acid is a fatty acid that can be incorporated into ceramide, a direct substrate for SMS2. Increased availability of Palmitic Acid can indirectly enhance the functional activity of SMS2. | ||||||