Oleic Acid CAS: 112-80-1
MF: C18H34O2
MW: 282.46
An anti-proliferative agent and activator of PKC and CaMKII.

Oleic Acid (CAS 112-80-1)

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Synonym: cis-9-Octadecenoic acid;Elainic acid
Application An anti-proliferative agent and activator of PKC and CaMKII
CAS 등록번호: 112-80-1
순도: ≥99%
분자량: 282.46
분자식: C18H34O2
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Oleic Acid, a monounsaturated fatty acid originally derived from Olea europaea, has been shown to be an anti-proliferative agent. This compound has also been reported to promote neuronal differentiation in murine cell cultures. Mechanistic studies suggest that these Oleic Acid effects are mediated by PPARβ. Furthermore, Oleic Acid has demonstrated the ability to stimulate an increase in secretion of collagen I, TGF-β secretion, and extracellular signal-regulated kinase1/2. Oleic Acid is an activator of PKC and CaMKII.


References

1. Díaz-Guerra, M.J., et al. 1991. J. Biol. Chem. 266: 23568-23576. PMID: 1748635
2. Waterman, E., et al. 2007. Altern Med Rev. 12: 331-342. PMID: 18069902
3. Di Loreto, S., et al. 2007. J. Cell. Physiol. 211: 837-847. PMID: 17390299
4. Mishra, R., et al. 2008. Arterioscler. Thromb. Vasc. Biol. 28: 541-547. PMID: 18096831

Appearance :
Oil
Physical State :
Liquid
용해도 :
Soluble in ethanol (>25 mg/ml), ether, acetone, chloroform, DMF (100 mg/ml), DMSO (100 mg/ml), and PBS (pH 7.2) (<100 µg/ml).
저장 :
Store at -20° C
녹는점 :
13-14° C (lit.)
비등점 :
194-195° C (lit.) at 1.2 mmHg
밀도 :
0.89 g/mL at 25° C
굴절률 :
n20D 1.46
IC50 :
DNA topoisomerase I: IC50 = 31000 nm (human); Fatty acid binding protein adipocyte: IC50 = 26100 nm (human)
Ki 데이타 :
Fatty acid-binding protein, liver: Ki= 180 nm (Rattus norvegicus); Fatty acid binding protein adipocyte: Ki= 185 nm (human); Fatty acid binding protein epidermal: Ki= 248 nm (human)
pK Values :
pKa: 4.78
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
1
RTECS :
RG2275000
PubChem CID :
445639
Merck Index :
14: 6828
MDL Number :
MFCD00064242
EC Number :
204-007-1
Beilstein Registry :
1726542
SMILES :
CCCCCCCC/C=C\\CCCCCCCC(=O)O

SDS(MSDS)다운로드

분석증명서

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Oleic Acid  논문정보

다른 사용자의 Oleic Acid사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 3 of {3} total

PMID: # 28819452  Chen, L. et al. 2017. Theranostics. 7: 2634-2648.

PMID: # 19808663  Kansanen, E. et al. 2009. J. Biol. Chem. 284: 33233-33241.

PMID: # 32157714  J. Food Biochem. e13177.

Citations 1 to 3 of {3} total
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