Linoleic Acid CAS: 60-33-3
MF: C18H32O2
MW: 280.44
A fatty acid with cytotoxic activity that influences the inflammatory process.

Linoleic Acid (CAS 60-33-3)

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Synonym: Telfairic Acid; 9-cis,12-cis-Octadecadienoic acid
Application A fatty acid with cytotoxic activity that influences the inflammatory process
CAS 등록번호: 60-33-3
순도: ≥99%
분자량: 280.44
분자식: C18H32O2
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Linoleic Acid is a fatty acid that has been observed to influence the inflammatory process and regulate the functions of neutrophils. Research has demonstrated that Linoleic Acid has cytotoxic activity and induces cell apoptosis by augmenting cellular oxidant status and inducing mitochondrial dysfunction. Additionally, the compound has been shown to stimulate the growth of MDA-MB-231 cells, increase the production of thromboxanes and prostaglandins, and reduce the levels of HHT and HETE. Linoleic Acid is an activator of PPAR.


References

1. Srivastava, K.C., et al. 1982. Prostaglandins Leukot Med. 9: 669-684. PMID: 6818563
2. Rose, D.P., et al. 1994. Cancer Res. 54: 6557-6562. PMID: 7987856
3. Rodrigues, H.G., et al. 2010. Lipids. 45: 809-819. PMID: 20730605
4. Lu, X., et al. 2010. Lipids Health Dis. 9: 106. PMID: 20868498

Physical State :
Liquid
용해도 :
Soluble in DMSO, ethanol, ether, acetone, and benzene. Insoluble in water.
저장 :
Store at -20° C
녹는점 :
-5° C (lit.)
비등점 :
229-230° C (lit.) at 16 mmHg
밀도 :
0.90 g/mL at 25° C (lit.)
굴절률 :
n20D 1.47 (lit.)
IC50 :
GPR40: EC5050 = 0.54 µM; COX1: IC50 = 13 µM; LO1: IC50 = 1 µM (soybean)
pK Values :
pKa: 4.77
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
1
RTECS :
RF9990000
PubChem CID :
5280450
Merck Index :
14: 5505
MDL Number :
MFCD00064241
EC Number :
200-470-9
Beilstein Registry :
1727101
SMILES :
CCCCCC=CCC=CCCCCCCCC(=O)O

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Linoleic Acid  논문정보

다른 사용자의 Linoleic Acid사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 3 of {3} total

PMID: # 28973946  Lopez, MS. et al. 2017. Proc. Natl. Acad. Sci. U.S.A. 114: 11223-11228.

PMID: # 15170673  Kohno, H. et al. 2004. Int. J. Cancer. 110: 896-901.

PMID: # 32157714  J. Food Biochem. e13177.

Citations 1 to 3 of {3} total
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