SMC6 Antibody (C-4): sc-515163
- SMC6 Antibody (C-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 975-997 near the C-terminus of SMC6 of human origin
- recommended for detection of SMC6 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-515163 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SMC6 Antibody (C-4) for WB applications. These reagents are now offered in bundles with SMC6 Antibody (C-4) (see ordering information below).
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SMC6 Antibody (C-4) is a mouse monoclonal IgG2a light chain antibody that detects SMC6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMC6 plays a vital role in the maintenance of genomic integrity, particularly in DNA repair mechanisms. SMC6 forms a heterodimeric complex with SMC5, which is essential for homologous recombination repair of double-stranded breaks in DNA. This process is crucial for preventing genomic instability, which can lead to various diseases, including cancer. The SMC5/SMC6 complex is also involved in the regulation of SUMOylation, a post-translational modification that influences protein interactions and stability, thereby enhancing the cell′s ability to respond to DNA damage. By facilitating the repair of DNA breaks and preventing chromosomal rearrangements, anti-SMC6 antibody (C-4) serves as an invaluable tool for researchers studying DNA repair pathways and their implications in disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SMC6 Antibody (C-4) References:
- Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. | Fujioka, Y., et al. 2002. J Biol Chem. 277: 21585-91. PMID: 11927594
- SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. | Torres-Rosell, J., et al. 2005. Nat Cell Biol. 7: 412-9. PMID: 15793567
- Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. | De Piccoli, G., et al. 2006. Nat Cell Biol. 8: 1032-4. PMID: 16892052
- Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. | Hwang, JY., et al. 2008. DNA Repair (Amst). 7: 1426-36. PMID: 18585101
- Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. | Pebernard, S., et al. 2008. Mol Biol Cell. 19: 4099-109. PMID: 18667531
- Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. | Duan, X., et al. 2009. J Biol Chem. 284: 8507-15. PMID: 19141609
- Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes. | Outwin, EA., et al. 2009. Mol Cell Biol. 29: 4363-75. PMID: 19528228
- The Smc5-Smc6 complex is required to remove chromosome junctions in meiosis. | Farmer, S., et al. 2011. PLoS One. 6: e20948. PMID: 21731634
- DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex. | Roy, MA. and D'Amours, D. 2011. Biochem Biophys Res Commun. 416: 80-5. PMID: 22086171
- DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants. | Chen, YH., et al. 2013. Mol Biol Cell. 24: 2431-41. PMID: 23783034
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMC6 Antibody (C-4) | sc-515163 | 200 µg/ml | $322.00 | |||
SMC6 Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-538750 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMC6 Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-536417 | 200 µg Ab; 40 µg BP | $361.00 | |||
SMC6 Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-548394 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMC6 (C-4) Neutralizing Peptide | sc-515163 P | 100 µg/0.5 ml | $69.00 | |||
SMC6 Antibody (C-4) X | sc-515163 X | 200 µg/0.1 ml | $322.00 |