Date published: 2026-1-30

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SMC Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of SMC Antibodies for studying structural maintenance of chromosomes proteins. SMC Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). SMC proteins play a vital role in chromosome organization, segregation, and DNA repair, maintaining genomic stability during cell division. Proper SMC protein function prevents chromosomal abnormalities that can lead to various diseases, including cancer. Understanding SMC protein dynamics provides insights into fundamental cellular processes and potential therapeutic targets. Research in chromosome biology has revealed SMC proteins as key regulators of genome maintenance and cell cycle progression. Investigating SMC protein mechanisms helps uncover new approaches for treating chromosomal disorders and developmental abnormalities. Current studies focus on how SMC proteins coordinate with other cellular factors to ensure accurate DNA distribution during mitosis and meiosis. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of chromosome biology and contribute to breakthrough discoveries in cell division research.

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SMC Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SMC1 Antibody (C2M)

sc-56776mouse IgG1 κ402-894 (h)WB, IPh
1
(4)

SMC1α Antibody (H-6)

sc-393171mouse IgG3 κ1202-1233 (h)WB, IP, IF, ELISAm, r, h
3
(2)

SMC1α Antibody (E-8)

sc-166734mouse IgM κInternal (h)WB, IP, IF, ELISAm, r, h

new

(1)

SMC3 Antibody (E-3)

sc-376352mouse IgG1 κ811-1110 (h)WB, IP, IF, IHC(P), ELISAm, r, h
5
(7)

SMC3 Antibody (A-7)

sc-365540mouse IgG3 κ1163-1188 (r)WB, IP, IF, ELISAm, r, h

new

(1)

SMC5 Antibody (B-11)

sc-393282mouse IgG2a κ901-1090 (h)WB, IP, IF, ELISAm, r, h
3
(2)

SMC6 Antibody (A-3)

sc-365742mouse IgG1 κ845-1072 (h)WB, IP, IF, ELISAm, r, h
6
(3)

SMC6 Antibody (C-4)

sc-515163mouse IgG2a κ975-997 (h)WB, IP, IF, ELISAh

new

(0)

Phospho-Specific SMC Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p-SMC1 Antibody (5D11G5)

sc-56746mouse IgG1 κSer 957 (h)WB, IP, IF, IHC(P)m, r, h

new

(2)

p-SMC1 Antibody (4H374)

sc-71790mouse IgG1 κSer 957 (h)WB, IP, IFm, r, h

new

(1)

p-SMC1 Antibody (5H24)

sc-71789mouse IgG1 κSer 957 (h)WB, IP, IFm, r, h

new

(1)

p-SMC1α Antibody (43.Ser 966)

sc-135784mouse IgG2b κSer 966 (m)WB, IP, ELISAm, r, h

new

(1)

SMC CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SMC1 CRISPR/Cas9 KO Plasmid (h)

sc-403715hGene KnockoutGFP0
(0)

SMC1 HDR Plasmid (h)

sc-403715-HDRhHomology Directed RepairPuromycin0
(0)

SMC1α CRISPR/Cas9 KO Plasmid (h)

sc-402865hGene KnockoutGFP0
(0)

SMC1α HDR Plasmid (h)

sc-402865-HDRhHomology Directed RepairPuromycin0
(0)

SMC2 Double Nickase Plasmid (h)

sc-411488-NIChGene KnockoutPuromycin0
(0)

SMC4 CRISPR/Cas9 KO Plasmid (h)

sc-405067hGene KnockoutGFP0
(0)

SMC4 HDR Plasmid (h)

sc-405067-HDRhHomology Directed RepairPuromycin0
(0)

SMC6 CRISPR/Cas9 KO Plasmid (h)

sc-402805hGene KnockoutGFP0
(0)

SMC6 HDR Plasmid (h)

sc-402805-HDRhHomology Directed RepairPuromycin0
(0)

SMC6 Double Nickase Plasmid (h)

sc-402805-NIChGene KnockoutPuromycin0
(0)

SMC6 Double Nickase Plasmid (h2)

sc-402805-NIC-2hGene KnockoutPuromycin0
(0)

SMC CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SMC1 CRISPR Activation Plasmid (h)

sc-403715-ACThGene ActivationPuro, Blast, Hygro0
(0)

SMC1α CRISPR Activation Plasmid (h)

sc-402865-ACThGene ActivationPuro, Blast, Hygro0
(0)

SMC1α CRISPR Activation Plasmid (h2)

sc-402865-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

SMC3 CRISPR Activation Plasmid (h)

sc-403950-ACThGene ActivationPuro, Blast, Hygro0
(0)

SMC4 CRISPR Activation Plasmid (h)

sc-405067-ACThGene ActivationPuro, Blast, Hygro0
(0)

SMC6 CRISPR Activation Plasmid (h)

sc-402805-ACThGene ActivationPuro, Blast, Hygro0
(0)

SMC6 CRISPR Activation Plasmid (h2)

sc-402805-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

SMC siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SMC1 siRNA (h)

sc-63348hGene SilencingN/A0
(0)

SMC1α siRNA (h)

sc-38385hGene SilencingN/A0
(0)

SMC1α siRNA (h2)

sc-38387hGene SilencingN/A0
(0)

SMC1α shRNA Plasmid (h)

sc-38385-SHhGene SilencingPuromycin0
(0)

SMC1α shRNA Plasmid (h2)

sc-38387-SHhGene SilencingPuromycin0
(0)

SMC1α shRNA (h) Lentiviral Particles

sc-38385-VhGene SilencingPuromycin0
(0)

SMC1α shRNA (h2) Lentiviral Particles

sc-38387-VhGene SilencingPuromycin0
(0)

SMC1α siRNA (m)

sc-38386mGene SilencingN/A0
(0)

SMC1α shRNA Plasmid (m)

sc-38386-SHmGene SilencingPuromycin0
(0)

SMC1α shRNA (m) Lentiviral Particles

sc-38386-VmGene SilencingPuromycin0
(0)

SMC1β shRNA Plasmid (h)

sc-63348-SHhGene SilencingPuromycin0
(0)

SMC1β shRNA (h) Lentiviral Particles

sc-63348-VhGene SilencingPuromycin0
(0)

SMC1β siRNA (m)

sc-38388mGene SilencingN/A0
(0)

SMC1β shRNA Plasmid (m)

sc-38388-SHmGene SilencingPuromycin0
(0)

SMC1β shRNA (m) Lentiviral Particles

sc-38388-VmGene SilencingPuromycin0
(0)

SMC2 siRNA (h)

sc-38389hGene SilencingN/A0
(0)

SMC2 shRNA Plasmid (h)

sc-38389-SHhGene SilencingPuromycin0
(0)

SMC2 shRNA (h) Lentiviral Particles

sc-38389-VhGene SilencingPuromycin0
(0)

SMC2 siRNA (m)

sc-38390mGene SilencingN/A0
(0)

SMC2 shRNA Plasmid (m)

sc-38390-SHmGene SilencingPuromycin0
(0)

SMC2 shRNA (m) Lentiviral Particles

sc-38390-VmGene SilencingPuromycin0
(0)

SMC3 siRNA (h)

sc-38391hGene SilencingN/A0
(0)

SMC3 shRNA Plasmid (h)

sc-38391-SHhGene SilencingPuromycin0
(0)

SMC3 shRNA (h) Lentiviral Particles

sc-38391-VhGene SilencingPuromycin0
(0)

SMC3 siRNA (m)

sc-38392mGene SilencingN/A0
(0)

SMC3 shRNA Plasmid (m)

sc-38392-SHmGene SilencingPuromycin0
(0)

SMC3 shRNA (m) Lentiviral Particles

sc-38392-VmGene SilencingPuromycin0
(0)

SMC4 siRNA (h)

sc-38384hGene SilencingN/A0
(0)

SMC4 shRNA Plasmid (h)

sc-38384-SHhGene SilencingPuromycin0
(0)

SMC4 shRNA (h) Lentiviral Particles

sc-38384-VhGene SilencingPuromycin0
(0)

SMC4 siRNA (m)

sc-153620mGene SilencingN/A0
(0)

SMC4 shRNA Plasmid (m)

sc-153620-SHmGene SilencingPuromycin0
(0)

SMC4 shRNA (m) Lentiviral Particles

sc-153620-VmGene SilencingPuromycin0
(0)

SMC5 siRNA (h)

sc-61563hGene SilencingN/A0
(0)

SMC5 shRNA Plasmid (h)

sc-61563-SHhGene SilencingPuromycin0
(0)

SMC5 shRNA (h) Lentiviral Particles

sc-61563-VhGene SilencingPuromycin0
(0)

SMC5 siRNA (m)

sc-61564mGene SilencingN/A0
(0)

SMC5 shRNA Plasmid (m)

sc-61564-SHmGene SilencingPuromycin0
(0)

SMC5 shRNA (m) Lentiviral Particles

sc-61564-VmGene SilencingPuromycin0
(0)

SMC6 siRNA (h)

sc-61565hGene SilencingN/A0
(0)

SMC6 shRNA Plasmid (h)

sc-61565-SHhGene SilencingPuromycin0
(0)

SMC6 shRNA (h) Lentiviral Particles

sc-61565-VhGene SilencingPuromycin0
(0)

SMC6 siRNA (m)

sc-61566mGene SilencingN/A0
(0)

SMC6 shRNA Plasmid (m)

sc-61566-SHmGene SilencingPuromycin0
(0)

SMC6 shRNA (m) Lentiviral Particles

sc-61566-VmGene SilencingPuromycin0
(0)