SIRT7 Antibody (C-3): sc-365344
- SIRT7 Antibody (C-3) is a mouse monoclonal IgG1 κ SIRT7 antibody, cited in 33 publications, provided at 200 µg/ml
- raised against amino acids 1-105 mapping at the N-terminus of SIRT7 of human origin
- SIRT7 Antibody (C-3) is recommended for detection of SIRT7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SIRT7 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SIRT7 Antibody (C-3) for WB applications. These reagents are now offered in bundles with SIRT7 Antibody (C-3) (see ordering information below).
SIRT7 Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SIRT7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SIRT7 (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SIRT7, also known as NAD-dependent deacetylase sirtuin-7 or SIR2L7, is a member of the class IV sirtuin family and is primarily localized in the nucleolus, where SIRT7 plays a crucial role in regulating ribosomal DNA transcription. This localization is significant because SIRT7 interacts with histones associated with rDNA genes, acting as a positive regulator of RNA polymerase I activity. By enhancing Pol I-mediated transcription, SIRT7 contributes to ribosome biogenesis and cellular growth, which is particularly important in the context of cancer, as SIRT7 expression is upregulated in thyroid carcinoma cells. Additionally, SIRT7 undergoes post-translational modifications, including acetylation, which can influence activity and stability, further underscoring SIRT7′s role in cellular regulation and potential implications in tumorigenesis. With diverse applications and critical biological functions, anti-SIRT7 antibody (C-3) is an essential tool for researchers studying the mechanisms of gene expression and the role of sirtuins in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SIRT7 Antibody (C-3) References:
- Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | Frye, RA. 2000. Biochem Biophys Res Commun. 273: 793-8. PMID: 10873683
- 'SIRT8' expressed in thyroid cancer is actually SIRT7. | Frye, R. 2002. Br J Cancer. 87: 1479. PMID: 12454781
- Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. | Michishita, E., et al. 2005. Mol Biol Cell. 16: 4623-35. PMID: 16079181
- Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. | Mostoslavsky, R., et al. 2006. Cell. 124: 315-29. PMID: 16439206
- Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. | Voelter-Mahlknecht, S., et al. 2006. Int J Oncol. 28: 899-908. PMID: 16525639
- Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. | Ford, E., et al. 2006. Genes Dev. 20: 1075-80. PMID: 16618798
- Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. | Vakhrusheva, O., et al. 2008. Circ Res. 102: 703-10. PMID: 18239138
- SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. | Bi, S., et al. 2020. Protein Cell. 11: 483-504. PMID: 32504224
- SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. | Li, G., et al. 2020. EMBO J. 39: e104365. PMID: 32696520
- O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction. | He, X., et al. 2022. Cell Death Differ. 29: 1970-1981. PMID: 35422493
- SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation. | Yi, X., et al. 2023. Signal Transduct Target Ther. 8: 107. PMID: 36918544
- Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation. | Zhang, J., et al. 2024. Cardiovasc Res. 120: 403-416. PMID: 38198357
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIRT7 Antibody (C-3) | sc-365344 | 200 µg/ml | $316.00 | |||
SIRT7 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-527358 | 200 µg Ab; 10 µg BP | $354.00 | |||
SIRT7 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-532731 | 200 µg Ab; 20 µg BP | $354.00 | |||
SIRT7 Antibody (C-3) AC | sc-365344 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SIRT7 Antibody (C-3) HRP | sc-365344 HRP | 200 µg/ml | $316.00 | |||
SIRT7 Antibody (C-3) FITC | sc-365344 FITC | 200 µg/ml | $330.00 | |||
SIRT7 Antibody (C-3) PE | sc-365344 PE | 200 µg/ml | $343.00 | |||
SIRT7 Antibody (C-3) Alexa Fluor® 488 | sc-365344 AF488 | 200 µg/ml | $357.00 | |||
SIRT7 Antibody (C-3) Alexa Fluor® 546 | sc-365344 AF546 | 200 µg/ml | $357.00 | |||
SIRT7 Antibody (C-3) Alexa Fluor® 594 | sc-365344 AF594 | 200 µg/ml | $357.00 | |||
SIRT7 Antibody (C-3) Alexa Fluor® 647 | sc-365344 AF647 | 200 µg/ml | $357.00 | |||
SIRT7 Antibody (C-3) Alexa Fluor® 680 | sc-365344 AF680 | 200 µg/ml | $357.00 | |||
SIRT7 Antibody (C-3) Alexa Fluor® 790 | sc-365344 AF790 | 200 µg/ml | $357.00 |