Anti-SIRT7 Antibody (C-3) is a mouse monoclonal IgG1 κ SIRT7 antibody, cited in 19 publications, provided at 200 µg/ml
raised against amino acids 1-105 mapping at the N-terminus of SIRT7 of human origin
Anti-SIRT7 Antibody (C-3) is recommended for detection of SIRT7 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-SIRT7 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of SIRT7 (C-3): sc-365344.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SIRT7 Antibody (C-3) for WB applications. These reagents are now offered in bundles with SIRT7 Antibody (C-3) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
SIRT7 Antibody (C-3) is a high quality monoclonal SIRT7 antibody (also designated Sirtuin 7 antibody) suitable for the detection of the SIRT7 protein of mouse, rat and human origin. SIRT7 Antibody (C-3) is available as both the non-conjugated anti-SIRT7 antibody form, as well as multiple conjugated forms of anti-SIRT7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Sirtuins (SIRT1-7) are human homologs of the yeast Sir2 (silent information regulator-2) protein and are divided into four main classes: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. In S. cerevisiae, Sir2 deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA (ribosomal DNA) and silent mating-type loci. The human SIRT proteins are NAD-dependent deacetylases that act as intracellular regulators and are thought to have ribosyltransferase activity. SIRT7 (NAD-dependent deacetylase sirtuin-7), also known as SIR2L7, is a member of the class IV sirtuin family and is localized to the nucleolus. Expressed throughout the body, SIRT7 associates with rDNA genes where it interacts with histones and acts as a positive regulator of RNA polymerase I (Pol I). SIRT7 is a probable NAD-dependent deacetylase whose expression is upregulated in thyroid carcinoma cells. Overexpression of SIRT7 increases Pol I-mediated transcription, thereby speeding cell growth and contributing to the development of cancer. Two isoforms exist due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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