SIRT7 Activators
SIRT7 Activators are a class of chemical compounds that play a significant role in the modulation of Sirtuin 7 (SIRT7), a member of the sirtuin family of NAD+-dependent protein deacetylases. SIRT7 is primarily localized within the nucleus and is involved in various cellular processes, particularly those related to chromatin regulation and gene expression. One of its key functions is the deacetylation of histone proteins, which are essential components of chromatin and play a crucial role in controlling gene transcription. SIRT7 acts as an epigenetic regulator by removing acetyl groups from specific histone residues, thus affecting the chromatin structure and influencing gene expression patterns.
The mechanism of action of SIRT7 Activators typically involves binding to specific regions of the SIRT7 protein, inducing conformational changes that can enhance or inhibit its deacetylase activity. By modulating SIRT7 activity, these activators impact gene expression, chromatin structure, and cellular processes regulated by SIRT7-mediated deacetylation. Research into SIRT7 Activators provides valuable insights into the complex regulatory mechanisms governing epigenetic modifications and gene regulation. Understanding how these activators interact with SIRT7 contributes to our knowledge of the intricate processes involved in epigenetic control of gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol with calorie restriction mimetic properties. As an activator of SIRT1, resveratrol may increase SIRT7 expression through crosstalk between sirtuin family members or activation of stress response signaling pathways involved in their coordinated transcriptional regulation. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol is an endogenous metabolite of estradiol with anti-tumor effects. SIRT7 participates in DNA damage responses and cell cycle regulation, processes 2-methoxestradiol may activate to help prevent oncogenic transformations, thereby stimulating SIRT7 transcription. | ||||||
Pentadecafluorooctanoic acid | 335-67-1 | sc-250662 sc-250662A | 5 g 25 g | $50.00 $152.00 | ||
Pentadecafluorooctanoic acid is a persistent organic pollutant that can disrupt metabolism and induce oxidative stress. These effects signal through cellular stress pathways which SIRT7 responds to help maintain genome stability, implying SIRT7 levels may rise in compensation upon perfluorooctanoic acid exposure. | ||||||
Arsenic sponge | 7440-38-2 | sc-278710 | 25 g | $236.00 | ||
Arsenic is a natural element and groundwater contaminant linked to various cancers. It inducES oxidative stress and causes DNA lesions SIRT7 helps repair through homology-directed repair. Prolonged arsenic exposure could increase SIRT7 expression via chronic DNA damage signaling. | ||||||