SIRT7 Inhibitors
SIRT7 inhibitors belong to a distinct chemical class characterized by their ability to selectively target and inhibit the activity of the Sirtuin 7 (SIRT7) enzyme. SIRT7 is a member of the sirtuin family of NAD+-dependent deacetylases, which play critical roles in cellular processes such as gene expression regulation, DNA repair, and metabolic homeostasis. Specifically, SIRT7 is primarily localized within the cell's nucleus and is known for its involvement in chromatin structure maintenance and gene transcription regulation. Its deacetylase activity is responsible for removing acetyl groups from histone proteins and non-histone substrates, thereby influencing chromatin compaction and modulating the expression of genes associated with various cellular functions.
SIRT7 inhibitors, as the name suggests, are compounds designed to interfere with the enzymatic activity of SIRT7. By binding to the active site of the enzyme or altering its conformation, these inhibitors effectively block SIRT7's deacetylase function. This selective inhibition of SIRT7 can have profound implications for cellular processes and functions that rely on SIRT7's enzymatic activity. Researchers are actively studying these inhibitors to better understand their mechanisms and applications, particularly in the context of basic research and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 and a precursor to NAD+. It can act as a sirtuin inhibitor by competing with NAD+ for binding to the active site of the enzyme, potentially reducing the deacetylase activity of SIRT7. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
EX 527 is a selective inhibitor of SIRT1, but it has also been reported to inhibit other sirtuins, including SIRT7, at higher concentrations. It binds to the NAD+ binding site, preventing the enzyme from catalyzing its reaction. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
Sirtinol is a known inhibitor of sirtuin activity, and while it is more selective for SIRT1 and SIRT2, it can also inhibit SIRT7. Sirtinol interferes with the binding of NAD+ to the active site of the enzyme. | ||||||
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $48.00 | ||
Splitomicin is another compound that preferentially inhibits SIRT1 and SIRT2 but has also been reported to have inhibitory effects on SIRT7. It interferes with NAD+ binding and disrupts the enzymatic activity of sirtuins. | ||||||
Naphthol AS | 92-77-3 | sc-215536A sc-215536 | 25 g 500 g | $42.00 $162.00 | ||
Naphthol AS is a compound that has been reported to inhibit the deacetylase activity of SIRT7, although the mechanism is not well-understood. It is believed to interfere with the catalytic activity of the enzyme. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 is a small molecule that has been found to inhibit the activity of SIRT1 and SIRT2, with potential inhibitory effects on SIRT7 as well. It increases the levels of acetylated proteins in cells, suggesting a reduction in deacetylase activity. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin sodium has been reported to inhibit the activity of SIRT1, SIRT5, and potentially SIRT7. The exact mechanism of its inhibitory action on SIRT7 is not clear. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Thiazovivin is a small molecule that has been reported to inhibit the activity of various sirtuins, including SIRT7. It enhances the reprogramming of somatic cells to induced pluripotent stem cells, a process associated with changes in sirtuin activity. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $145.00 | 4 | |
Cambinol is a known sirtuin inhibitor that preferentially inhibits SIRT1 and SIRT2 but has also been reported to inhibit SIRT7 at higher concentrations. It binds to the sirtuin enzyme and interferes with its catalytic activity. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
Salermide is a compound originally developed as an inhibitor of SIRT1 and SIRT2, but it has also been shown to inhibit SIRT7. It induces apoptosis in cancer cells, and its activity against SIRT7 has been implicated in this process. | ||||||