Sigma Receptor Antibody (B-5): sc-137075

Sigma Receptor Antibody (B-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sigma Receptor of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Sigma Receptor (B-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sigma Receptor, also known as opioid receptor sigma 1 (Oprs 1), plays a crucial role in modulating intracellular signaling pathways, particularly in response to stress and pain. Sigma Receptor is primarily located in the endoplasmic reticulum and plasma membrane of neurons, where Sigma Receptor influences calcium signaling and neurotransmitter release, making Sigma Receptor vital for processes such as analgesia and neuroprotection. Sigma Receptor localization allows for rapid responses to various stimuli, including modulation of opioid effects and regulation of neurochemical systems involved in mood and cognition. Sigma Receptor is implicated in several psychiatric disorders and central nervous system diseases, highlighting Sigma Receptor importance in both health and disease. Pregnenolone and dehydroepiandrosterone, which act as Sigma Receptor agonists, further illustrate Sigma Receptor′s role in neurobiology, while progesterone serves as a potent antagonist, showcasing the complexity of these interactions. Understanding Sigma Receptor function and location is essential for developing therapeutic strategies targeting Sigma Receptor in various neurological and psychiatric conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Sigma Receptor Antibody (B-5) References:

1. Molecular cloning and pharmacological characterization of the rat sigma1 receptor.  |  Mei, J. and Pasternak, GW. 2001. Biochem Pharmacol. 62: 349-55. PMID: 11434908
2. The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities.  |  Maurice, T., et al. 2001. Brain Res Brain Res Rev. 37: 116-32. PMID: 11744080
3. Sigma1 receptor modulation of opioid analgesia in the mouse.  |  Mei, J. and Pasternak, GW. 2002. J Pharmacol Exp Ther. 300: 1070-4. PMID: 11861817
4. A putative sigma1 receptor antagonist NE-100 attenuates the discriminative stimulus effects of ketamine in rats.  |  Narita, M., et al. 2001. Addict Biol. 6: 373-376. PMID: 11900615
5. Sigma receptors: from molecule to man.  |  Ferris, CD., et al. 1991. J Neurochem. 57: 729-37. PMID: 1650393
6. Sigma receptors. Putative links between nervous, endocrine and immune systems.  |  Su, TP. 1991. Eur J Biochem. 200: 633-42. PMID: 1655424
7. Sigma receptors: biology and function.  |  Walker, JM., et al. 1990. Pharmacol Rev. 42: 355-402. PMID: 1964225
8. Potential applications for sigma receptor ligands in cancer diagnosis and therapy.  |  van Waarde, A., et al. 2015. Biochim Biophys Acta. 1848: 2703-14. PMID: 25173780
9. Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity.  |  Georgiadis, MO., et al. 2017. Molecules. 22: PMID: 28841173
10. Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding.  |  Mercer, RCC., et al. 2024. ACS Chem Neurosci. 15: 2265-2282. PMID: 38743607
11. Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).  |  Kekuda, R., et al. 1996. Biochem Biophys Res Commun. 229: 553-8. PMID: 8954936
12. Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene.  |  Prasad, PD., et al. 1998. J Neurochem. 70: 443-51. PMID: 9453537

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sigma Receptor Antibody (B-5) has 78 citations in a variety of scientific publications.

Primary antibodies like Anti-Sigma Receptor Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sigma Receptor Antibody (B-5) Specifications

Alternate Product Name: Sigma Receptor

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 136-169

Epitope Target: Sigma Receptor

Epitope Species: human

Product Reactivity/Detection: Sigma Receptor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 78 citations in various scientific publications

Available Conjugates/Forms for Sigma Receptor Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Sigma Receptor antibody is Sigma Receptor Antibody (F-5): sc-166392.