Sigma Receptor Antibody (F-5): sc-166392

Sigma Receptor Antibody (F-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects Sigma Receptor of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sigma Receptor (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sigma Receptor, also known as opioid receptor sigma 1 (Oprs 1), plays a crucial role in modulating the analgesic effects of opioid drugs, making Sigma Receptor significant in pain management and therapeutic interventions. Sigma Receptor is primarily located in the endoplasmic reticulum and plasma membrane of neurons, where Sigma Receptor influences intracellular signaling pathways. Strategic positioning allows Sigma Receptor to interact with various signaling molecules, thereby modulating calcium mobilization and neurotransmitter release, which are vital for maintaining synaptic plasticity and overall neuronal health. Sigma Receptor is implicated in several neurobiological processes, including learning, memory, and responses to stress, depression, and neuroprotection. Research has shown Sigma Receptor interacts with specific proteins such as the NMDA receptor, which is essential for synaptic transmission and plasticity. Expression of Sigma Receptor in various human tumors and involvement in psychiatric disorders highlight potential as a therapeutic target in treating central nervous system diseases. Opioid analgesia is influenced by multiple factors, including Sigma Receptor activity, underscoring importance in both basic research and clinical applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sigma Receptor Antibody (F-5) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Sigma Receptor Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sigma Receptor Antibody (F-5) Specifications

Alternate Product Name: Sigma Receptor

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-223

Epitope Target: Sigma Receptor

Epitope Species: human

Product Reactivity/Detection: Sigma Receptor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Sigma Receptor Antibody (F-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Sigma Receptor antibody is Sigma Receptor Antibody (B-5): sc-137075.