Date published: 2025-10-8

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Sigma Receptor Activators

Sigma receptors, comprising sigma-1 and sigma-2 receptor subtypes, represent a unique class of proteins distributed across diverse tissues, encompassing the brain and peripheral organs. Unlike traditional receptors such as G-protein coupled receptors or ion channels, sigma receptors, specifically sigma-1 and sigma-2, offer distinctive features and functions that contribute to the complexity of cellular signaling. Sigma receptor activators, whether synthetic compounds or endogenous ligands, engage with and modulate the activity of these receptors. The intricate mechanisms through which these activators exert their effects are subjects of ongoing investigation, adding depth to our understanding of sigma receptor biology. Within the cellular landscape, sigma-1 receptors predominantly reside in the endoplasmic reticulum (ER), a vital organelle involved in protein and lipid synthesis and processing. Sigma-1 receptors play a pivotal role in regulating intracellular calcium levels, a critical factor governing diverse cellular functions. This involvement in calcium regulation positions sigma-1 receptors at the nexus of cellular homeostasis, contributing to the orchestration of fundamental processes within the ER. On the other hand, sigma-2 receptors are strategically located in the cell membrane, where they become implicated in crucial phenomena such as cell proliferation and differentiation. The distinctive subcellular localization of sigma-1 and sigma-2 receptors underscores their diverse roles in cellular physiology.Sigma receptor activators influence a myriad of cellular processes, spanning neurotransmission, cell survival, and stress responses. The multifaceted impact of these activators suggests a broad spectrum of cellular functions under sigma receptor modulation. The ongoing research endeavors in this field seek to unravel the specific roles of sigma receptor activators in normal physiological processes, aiming to shed light on their applications in disease states. The exploration of these activators not only enhances our comprehension of sigma receptor biology but also presents exciting prospects for interventions and the modulation of cellular functions in various pathological conditions. The evolving landscape of sigma receptor research holds promise for unveiling novel avenues in cellular signaling.

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Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DHEA

53-43-0sc-202573
10 g
$109.00
3
(1)

DHEA interacts with sigma receptors, influencing various intracellular signaling pathways. Its unique steroidal structure allows for selective binding, modulating receptor activity and downstream effects. The compound's lipophilic nature facilitates membrane penetration, enhancing its bioavailability. DHEA's role in receptor-mediated processes can alter neurotransmitter release and cellular responses, showcasing its potential to impact neurophysiological functions through distinct molecular interactions.

Fluvoxamine maleate

61718-82-9sc-203582
sc-203582A
10 mg
50 mg
$50.00
$220.00
(1)

Fluvoxamine maleate exhibits a notable affinity for sigma receptors, engaging in specific molecular interactions that influence cellular signaling. Its unique structural characteristics enable it to modulate receptor conformation, affecting downstream signaling cascades. The compound's hydrophilic properties enhance solubility, promoting effective receptor engagement. Additionally, its kinetic profile suggests a rapid onset of action, allowing for dynamic modulation of receptor-mediated pathways and cellular responses.

PRE-084 Hydrochloride

138847-85-5sc-203447
sc-203447A
10 mg
50 mg
$164.00
$689.00
3
(1)

PRE-084 Hydrochloride is a selective sigma receptor ligand that demonstrates unique binding dynamics, characterized by its ability to stabilize receptor conformations. This compound exhibits distinct interaction patterns that facilitate the modulation of intracellular signaling pathways. Its lipophilic nature enhances membrane permeability, allowing for efficient receptor access. Furthermore, PRE-084 Hydrochloride's reaction kinetics indicate a prolonged engagement with sigma receptors, influencing various cellular processes.

Carbetapentane

77-23-6sc-201100
sc-201100A
100 mg
500 mg
$300.00
$400.00
1
(0)

Carbetapentane acts as a sigma receptor modulator, exhibiting unique allosteric effects that alter receptor activity. Its structural conformation allows for specific interactions with receptor sites, promoting distinct signaling cascades. The compound's hydrophobic characteristics enhance its affinity for lipid membranes, facilitating rapid receptor engagement. Additionally, Carbetapentane's kinetic profile suggests a dynamic equilibrium in receptor binding, influencing downstream cellular responses.

Carbetapentane citrate

23142-01-0sc-203538
100 mg
$114.00
(1)

Carbetapentane citrate functions as a sigma receptor ligand, characterized by its ability to selectively bind and modulate receptor conformations. This compound engages in unique hydrogen bonding and hydrophobic interactions, which stabilize receptor-ligand complexes. Its distinct stereochemistry contributes to varied receptor activation pathways, potentially influencing intracellular calcium signaling. The compound's solubility properties further enhance its interaction dynamics within biological membranes, promoting effective receptor modulation.

Fluvoxamine

54739-18-3sc-207697
25 mg
$315.00
1
(0)

Fluvoxamine acts as a sigma receptor ligand, exhibiting a unique affinity for specific receptor subtypes. Its molecular structure facilitates intricate π-π stacking interactions and dipole-dipole interactions, enhancing binding stability. The compound's conformational flexibility allows it to navigate diverse receptor environments, potentially influencing downstream signaling cascades. Additionally, its lipophilic characteristics enable effective membrane penetration, optimizing receptor engagement and modulation.

(+)-SKF 10047 hydrochloride

133005-41-1sc-204282
sc-204282A
10 mg
50 mg
$445.00
$1637.00
(0)

(+)-SKF 10047 hydrochloride is a selective sigma receptor ligand known for its unique binding dynamics. Its structural conformation promotes strong hydrogen bonding and hydrophobic interactions, which enhance receptor affinity. The compound's stereochemistry plays a crucial role in its interaction profile, allowing it to selectively modulate receptor activity. Furthermore, its ability to traverse lipid membranes efficiently supports its engagement with sigma receptors, influencing various intracellular pathways.

PB 28 dihydrochloride

172906-90-0sc-204834
sc-204834A
10 mg
50 mg
$137.00
$564.00
2
(0)

PB 28 dihydrochloride is a potent sigma receptor modulator characterized by its distinctive molecular architecture that facilitates specific receptor interactions. Its unique electronic properties enable effective charge distribution, enhancing binding affinity. The compound exhibits rapid kinetics in receptor engagement, promoting swift signal transduction. Additionally, its solubility profile allows for effective diffusion across cellular membranes, influencing downstream signaling cascades and cellular responses.

4-PPBP maleate

207572-62-1sc-203780
sc-203780A
10 mg
50 mg
$119.00
$450.00
(0)

4-PPBP maleate is a selective sigma receptor ligand known for its unique structural features that promote high specificity in receptor binding. The compound's stereochemistry plays a crucial role in its interaction dynamics, allowing for tailored conformational changes upon binding. Its hydrophilic nature enhances solubility in biological environments, facilitating efficient receptor engagement. Furthermore, 4-PPBP maleate demonstrates distinct allosteric modulation, influencing receptor activity and downstream signaling pathways.

(±)-PPCC oxalate

932736-90-8sc-358806
sc-358806A
10 mg
50 mg
$159.00
$665.00
(0)

(±)-PPCC oxalate is a notable sigma receptor ligand characterized by its unique ability to engage in specific molecular interactions that modulate receptor conformation. Its dual stereochemistry allows for versatile binding orientations, enhancing its affinity and selectivity. The compound exhibits intriguing kinetic properties, with rapid association and dissociation rates that facilitate dynamic receptor engagement. Additionally, its distinct electronic properties contribute to effective signaling modulation, impacting cellular responses.