SCO1 Antibody (B-1): sc-365407

SCO1 Antibody (B-1) is a mouse monoclonal IgG1 antibody that detects SCO1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCO1 is a vital inner membrane protein located in the mitochondrion, playing a crucial role in the insertion and transport of copper to the active site of cytochrome c oxidase (COX), which is essential for energy production as it serves as the terminal enzyme in the respiratory chain. The proper functioning of SCO1 is particularly important in tissues with high oxidative phosphorylation demands, such as the brain, heart, and muscle, where SCO1 is predominantly expressed. Deficiencies in the SCO1 gene can lead to cytochrome c oxidase deficiency, a heterogeneous disorder that disrupts cellular energy metabolism. Furthermore, SCO1′s interaction with other proteins involved in mitochondrial function underscores SCO1′s significance in maintaining cellular health and energy balance. Anti-SCO1 antibody (B-1) is an invaluable tool for researchers investigating mitochondrial function and related disorders, providing insights into the molecular mechanisms underlying energy production and its associated pathologies.

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SCO1 Antibody (B-1) References:

1. Defects in mitochondrial respiratory complexes III and IV, and human pathologies.  |  Borisov, VB. 2002. Mol Aspects Med. 23: 385-412. PMID: 12231008
2. Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1.  |  Williams, SL., et al. 2004. J Biol Chem. 279: 7462-9. PMID: 14607829
3. Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein.  |  Williams, JC., et al. 2005. J Biol Chem. 280: 15202-11. PMID: 15659396
4. Crystal structure of yeast Sco1.  |  Abajian, C. and Rosenzweig, AC. 2006. J Biol Inorg Chem. 11: 459-66. PMID: 16570183
5. Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer.  |  Banci, L., et al. 2008. Proc Natl Acad Sci U S A. 105: 6803-8. PMID: 18458339
6. Loss of function of Sco1 and its interaction with cytochrome c oxidase.  |  Stiburek, L., et al. 2009. Am J Physiol Cell Physiol. 296: C1218-26. PMID: 19295170
7. Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.  |  Leary, SC., et al. 2009. Hum Mol Genet. 18: 2230-40. PMID: 19336478
8. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene.  |  Porcelli, D., et al. 2010. Mitochondrion. 10: 433-48. PMID: 20388558
9. Novel mutations in SCO1 as a cause of fatal infantile encephalopathy and lactic acidosis.  |  Leary, SC., et al. 2013. Hum Mutat. 34: 1366-70. PMID: 23878101
10. The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.  |  Hlynialuk, CJ., et al. 2015. Cell Rep. 10: 933-943. PMID: 25683716

The preferred SCO1 antibody is SCO1 Antibody (D-1): sc-398001.